Results 121 to 130 of about 953,634 (315)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Resultados preliminares de la evaluación del primer sistema látex en el diagnóstico rápido de la leptospirosis humana en Cuba Preliminary results of the evaluation of the first latex system in the rapid diagnosis of human leptospirosis in Cuba

Revista Cubana de Higiene y Epidemiología, 2005
Se elaboró un látex de aglutinación de producción nacional (leptospira - látex - IPK) para el diagnóstico rápido de la leptospirosis humana. La dilución óptima de trabajo del antígeno termorresistente (TR) acoplado a las partículas de látex fue de 1/80 ...
Ana Margarita Obregón Fuentes, Carmen Fernández Molina, María del Carmen Batlle, José Rodríguez, Islay Rodríguez, Idalmis Hernández   +5 more
doaj  

Molecular epidemiology and phylogenetic analysis of influenza viruses A (H3N2) and B/Victoria during the COVID-19 pandemic in Guangdong, China

Infectious Diseases of Poverty
Background Non-pharmaceutical measures and travel restrictions have halted the spread of coronavirus disease 2019 (COVID-19) and influenza. Nonetheless, with COVID-19 restrictions lifted, an unanticipated outbreak of the influenza B/Victoria virus in ...
Zhiqi Zeng, Yong Liu, Wenxiang Jin, Jingyi Liang, Jinbin Chen, Ruihan Chen, Qianying Li, Wenda Guan, Lixi Liang, Qiubao Wu, Yuanfang Lai, Xiaoyan Deng, Zhengshi Lin, Chitin Hon, Zifeng Yang   +14 more
doaj   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Rapid and specific detection of Streptococcus suis serotype 2 using a RPA–PfAgo system coupled with fluorescence and lateral flow dipstick

Frontiers in Veterinary Science
ObjectiveTo develop and validate dual detection platforms integrating recombinase polymerase amplification (RPA) with Pyrococcus furiosus Argonaute (PfAgo) for the rapid and specific identification of Streptococcus suis serotype 2.MethodsThe conserved ...
Kexin Wang, Kexin Wang, Xujie Zhao, Xujie Zhao, Jingjing Li, Jingjing Li, Mingzhu Zhou, Mingzhu Zhou, Bingze Jiao, Bingze Jiao, Yilin Bai, Zhanwei Teng, Zhanwei Teng, Meinan Chang, Meinan Chang, Yueyu Bai, Jianhe Hu, Jianhe Hu, Ke Ding, Ke Ding, Xiaojing Xia, Xiaojing Xia   +21 more
doaj   +1 more source

Rapid sequencing‐based diagnosis of infectious bacterial species from meningitis patients in Zambia

Clinical & Translational Immunology, 2019
Objectives We have developed a portable system for the rapid determination of bacterial composition for the diagnosis of infectious diseases. Our system comprises of a nanopore technology‐based sequencer, MinION, and two laptop computers.
So Nakagawa, Shigeaki Inoue, Kirill Kryukov, Junya Yamagishi, Ayumu Ohno, Kyoko Hayashida, Ruth Nakazwe, Mox Kalumbi, Darlington Mwenya, Nana Asami, Chihiro Sugimoto, Mable M Mutengo, Tadashi Imanishi   +12 more
doaj   +1 more source

A Density Clustering RAPID Based on an Array-Compensated Damage Index for Quantitative Damage Diagnosis

Guided wave array-based structural health monitoring (SHM) is a promising solution for diagnosing damage in metal-connected structures. In this field, the reconstruction algorithm for probabilistic inspection (RAPID) is one of the most widely used ...
Tian Xie, Qiao Bao, Qiang Wang, Yan Zhuang   +3 more
core   +1 more source

Rapid Cardiovascular Diagnostics

, 2016
Rapid cardiovascular diagnostics have played an integral role in the development of the clinical utility of cardiac biomarkers. Rapid qualitative and quantitative tests are used as an alternative to clinical chemistry laboratories, where urgent testing ...
David C. Gaze, Gaze, D.C.
core   +1 more source

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source