Results 51 to 60 of about 953,634 (315)

Serological Benefit of SARS‐CoV‐2 Vaccination Relative to Infection in Children With Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with acute lymphoblastic leukemia (ALL) are at risk of severe outcomes from SARS‐CoV‐2 (SCV2). In the post‐pandemic context, where most children have been infected with SCV2, there are limited data on whether vaccination remains beneficial in children with ALL.
Janna R. Shapiro, Freda Qi, Karen Colwill, Alina D. Dorogy, Ying Liu, Michelle Science, Anne‐Claude Gingras, James M. Rini, Sumit Gupta, Sarah Alexander, Shelly Bolotin, Tania H. Watts   +11 more
wiley   +1 more source

Accurate, fast and cost-effective simultaneous detection of bacterial meningitis by qualitative PCR with high-resolution melting

BioTechniques, 2023
Neisseria meningitidis, Haemophilus influenzae and Streptococcus pneumoniae are leading causes of meningitis and acute invasive infections. PCR-based methods are widely used for the diagnosis and surveillance of bacterial pathogens because of their high ...
Ivano de Filippis, Aline Carvalho de Azevedo, Irene de Oliveira Lima, Nicolle F Lima Ramos, Claudia Ferreira de Andrade, Antonio ECC de Almeida   +5 more
doaj   +1 more source

Accuracy of Malaria Rapid Diagnostic Tests in Community Studies and their Impact on Treatment of Malaria in an Area with Declining Malaria Burden in North-Eastern Tanzania. [PDF]

, 2011
Despite some problems related to accuracy and applicability of malaria rapid diagnostic tests (RDTs), they are currently the best option in areas with limited laboratory services for improving case management through parasitological diagnosis and ...
Thor G Theander, Bygbjerg Ib C, Martha M Lemnge, Mmbando Bruno P, Lemnge Martha M, Deus S Ishengoma, Bruno P Mmbando, Francis Filbert, Magistrado, Pamela, Ishengoma Deus S, John PA Lusingu, Ishengoma, Deus S, Bygbjerg, Ib Christian, Mmbando, Bruno P, Theander, Thor G, Lemnge, Martha M, Pamela Magistrado, Theander Thor G, Alifrangis Michael, Ib C Bygbjerg, Francis, Filbert, Lusingu, John P A, Magistrado Pamela, Lusingu John PA, Michael Alifrangis, Alifrangis, Michael, Filbert Francis, Bygbjerg, Ib C, Lusingu, John Pa   +28 more
core   +1 more source

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

Development and clinical validation of a dual ddPCR assay for detecting carbapenem-resistant Acinetobacter baumannii in bloodstream infections

Frontiers in Microbiology
ObjectiveAcinetobacter baumannii (A. baumannii, AB) represents a major species of Gram-negative bacteria involved in bloodstream infections (BSIs) and shows a high capability of developing antibiotic resistance.
Xiaoxia Kou, Xiaoxia Kou, Detu Zhu, Yandong Zhang, Liyan Huang, Jiawei Liang, Ziman Wu, Ze Liu, Chushi Guan, Lin Yu, Lin Yu   +10 more
doaj   +1 more source

Implementing ideal health policy in a fragile health system: the example of expanding the use of malaria rapid diagnostic tests in mainland Tanzania. [PDF]

, 2011
Malaria confirmation before treatment provides an opportunity for improving the quality of malaria case management in endemic regions. However, increased coverage of this strategy is facing many organizational, logistical and technical challenges that ...
Jan Jacobs, de Bethune, Xavier, Masanja Irene M, Jacobs Jan, Irene M Masanja, Masanja, Irene M, Xavier de Bethune, de Bethune Xavier, Jacobs, Jan   +8 more
core   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Evaluation of a direct method for detecting extended-spectrum β-lactamase using the Cica-beta test on positive blood culture bottles

Microbiology Spectrum
The global prevalence of extended-spectrum β-lactamase (ESBL)-producing Enterobacterales is a growing concern, underscoring the need for rapid detection to enable timely, targeted therapy.
Tomohide Okinaka, Yuji Teshima, Yoshimi Furuno, Miho Takeishi, Ayami Tashiro, Yoko Matsuda, Ayumi Irie, Tomomi Marutani, Hidenobu Koga, Takashi Matono   +9 more
doaj   +1 more source

Laboratory Findings in Patients with Probable Dengue Diagnosis from an Endemic Area in Colombia in 2018

Viruses, 2021
As demonstrated with the novel coronavirus pandemic, rapid and accurate diagnosis is key to determine the clinical characteristic of a disease and to improve vaccine development.
Jenny C. Cardenas, Sandra Y. Giraldo-Parra, Maria U. Gonzalez, Lady Y. Gutierrez-Silva, Lucy Jaimes-Villamizar, Alba L. Roa-Parra, Daisy J. Carvajal, Hugo O. Valdivia, Juan F. Sanchez, Tonya M. Colpitts, Berlin Londono-Renteria   +10 more
doaj   +1 more source