Results 71 to 80 of about 4,824,315 (311)

Model of Care for People with Mental Disorder and Co-existing Substance Use Disorder (Dual Diagnosis)

, 2023
This Model of Care has been developed in partnership with HSE Social Inclusion, HSE Health and Wellbeing and the National Office of Suicide Prevention and in collaboration with voluntary bodies including Sec.39 agencies.
National Working Group for Dual Diagnosis
core  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Physical modeling of catchment area by rapid prototyping using GIS data

, 2006
Published ArticleThe purpose of the present work is to develop a methodology for making physical models of catchment areas and terrains by rapid prototyping (RP) using geographic information systems (GIS) data.
Theron, Elizabeth, Antunes, João Paulo, Agrawall, Sanat, de Beer, Deon J., Truscott, Michele   +4 more
core  

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Rapid Manufacturing of Patient-specific Shielding Masks, using RP in parallel with Metal Spraying

, 2005
Published ArticleThe purpose of the present work is to develop a methodology to manufacture patient‐specific models (lead masks) to be used as protective shields during cancer treatment, using 3D photography, rapid prototyping (RP) and metal spraying. It
Booysen, Gerrie J., Truscott, Michéle, de Beer, Deon J., Barnard, Ludrick J., van der Walt, Jakobus G.   +4 more
core  

Accuracy of Malaria Rapid Diagnostic Tests in Community Studies and their Impact on Treatment of Malaria in an Area with Declining Malaria Burden in North-Eastern Tanzania. [PDF]

, 2011
Despite some problems related to accuracy and applicability of malaria rapid diagnostic tests (RDTs), they are currently the best option in areas with limited laboratory services for improving case management through parasitological diagnosis and ...
Thor G Theander, Bygbjerg Ib C, Martha M Lemnge, Mmbando Bruno P, Lemnge Martha M, Deus S Ishengoma, Bruno P Mmbando, Francis Filbert, Magistrado, Pamela, Ishengoma Deus S, John PA Lusingu, Ishengoma, Deus S, Bygbjerg, Ib Christian, Mmbando, Bruno P, Theander, Thor G, Lemnge, Martha M, Pamela Magistrado, Theander Thor G, Alifrangis Michael, Ib C Bygbjerg, Francis, Filbert, Lusingu, John P A, Magistrado Pamela, Lusingu John PA, Michael Alifrangis, Alifrangis, Michael, Filbert Francis, Bygbjerg, Ib C, Lusingu, John Pa   +28 more
core   +1 more source

Real-time fluorescent multiple cross displacement amplification for rapid and sensitive Mycoplasma pneumoniae detection

Frontiers in Cellular and Infection Microbiology
Mycoplasma pneumoniae is a significant pathogen responsible for community-acquired pneumonia, predominantly affecting children and adolescents. Here, we devised a rapid method for M.
Fei Xiao, Yu Zhang, Wenjian Xu, Jin Fu, Xiaolan Huang, Nan Jia, Chunrong Sun, Zheng Xu, Baoying Zheng, Juan Zhou, Yi Wang, Lihui Meng   +11 more
doaj   +1 more source

Rapid diagnosis of pulmonary tuberculosis

Pan African Medical Journal, 2014
World Health Organization had estimated 9.4 million tuberculosis cases on 2009, with 1.7 million of deaths as consequence of treatment and diagnosis failures. Improving diagnostic methods for the rapid and timely detection of tuberculosis patients is critical to control the disease.
José Mauricio Hernéndez Sarmiento, Natalia Builes Restrepo, Gloria Isabel Mejéa, Elsa Zapata, Mary Alejandra Restrepo, Jaime Robledo'   +5 more
openaire   +3 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source