Results 71 to 80 of about 953,634 (315)

Abandoning presumptive antimalarial treatment for febrile children aged less than five years--a case of running before we can walk? [PDF]

, 2009
Current guidelines recommend that all fever episodes in African children be treated presumptively with antimalarial drugs. But declining malarial transmission in parts of sub-Saharan Africa, declining proportions of fevers due to malaria, and the ...
Catherine Goodman, Goodman Catherine, Snow, RW, Robert W Snow, Reyburn, H, Snow, Robert W., Hugh Reyburn, Snow Robert W, Reyburn Hugh, Snow, Robert, Reyburn, Hugh, Goodman, Catherine, Mike English, Goodman, C, English, M, English, Mike, Snow, Robert W, English Mike   +17 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Rapid diagnosis of pulmonary tuberculosis

Pan African Medical Journal, 2014
World Health Organization had estimated 9.4 million tuberculosis cases on 2009, with 1.7 million of deaths as consequence of treatment and diagnosis failures. Improving diagnostic methods for the rapid and timely detection of tuberculosis patients is critical to control the disease.
José Mauricio Hernéndez Sarmiento, Natalia Builes Restrepo, Gloria Isabel Mejéa, Elsa Zapata, Mary Alejandra Restrepo, Jaime Robledo'   +5 more
openaire   +3 more sources

Detection of Mycobacterium tuberculosis in sputum by gas chromatography-mass spectrometry of methyl mycocerosates released by thermochemolysis. [PDF]

, 2012
Tuberculosis requires rapid diagnosis to prevent further transmission and allow prompt administration of treatment. Current methods for diagnosing pulmonary tuberculosis lack sensitivity are expensive or are extremely slow.
Minnikin, David E, Geraint H Morgan, Mutetwa, Reggie, Mutetwa Reggie, O'Sullivan, Denise M, David E Minnikin, McNerney, Ruth, Morgan Geraint H., Simona C Nicoara, Bardwell Max W., Lee, Oona Y-C., Corbett, Elizabeth L., Lee, Oona Y-C, Nicoara, Simona C., O'Sullivan Denise M., Minnikin David E., Elizabeth L Corbett, Oona Y-C Lee, Lee Oona Y-C., Bardwell, Max W, Mungofa Stanley, O'Sullivan, Denise M., Denise M O'Sullivan, Bardwell, Max W., Max W Bardwell, Nicoara Simona C., McNerney Ruth, Reggie Mutetwa, Minnikin, David E., Corbett, Elizabeth L, Ruth McNerney, Morgan, Geraint H, Stanley Mungofa, Corbett Elizabeth L., Morgan, Geraint H., Mungofa, Stanley, Nicoara, Simona C   +36 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Rapid diagnosis of lung infections

Nature Biotechnology, 2019
Nanopore sequencing of the sputum metagenome identifies respiratory pathogens in six hours.
Andrei Prodan, Morten O. A. Sommer, Max Nieuwdorp   +2 more
openaire   +3 more sources

Willingness-to-pay for a rapid malaria diagnostic test and artemisinin-based combination therapy from private drug shops in Mukono District, Uganda. [PDF]

, 2013
In Uganda, as in many parts of Africa, the majority of the population seek treatment for malaria in drug shops as their first point of care; however, parasitological diagnosis is not usually offered in these outlets.
Cundill, Bonnie, Clarke, Sian, Mbonye, Anthony, Pedrazzoli, Debora, Yeung, Shunmay, Magnussen, Pascal, Hansen, Kristian Schultz   +6 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Real-time fluorescent multiple cross displacement amplification for rapid and sensitive Mycoplasma pneumoniae detection

Frontiers in Cellular and Infection Microbiology
Mycoplasma pneumoniae is a significant pathogen responsible for community-acquired pneumonia, predominantly affecting children and adolescents. Here, we devised a rapid method for M.
Fei Xiao, Yu Zhang, Wenjian Xu, Jin Fu, Xiaolan Huang, Nan Jia, Chunrong Sun, Zheng Xu, Baoying Zheng, Juan Zhou, Yi Wang, Lihui Meng   +11 more
doaj   +1 more source