Results 91 to 100 of about 4,824,315 (311)

Three‐dimensional plotting as a visualisation aid for architectural use

, 2004
Published ArticleFunctional design is closely linked to manufacturing and building. Designers' freedom to express themselves is often limited by the capabilities of craftsmen who have to give physical substance to the designer's ideas. This paper reviews
Booysen, Gerrie J., de Beer, Deon J., Barnard, Ludrick J.   +2 more
core  

Printing Press, Rapid City SD, Pennington County

4 x 5 photograph, a printing pressTowns Provo - Rapid City P35 Tab R Poster board Rapid City P35 [stamp] Property of South Dakota State Historical Society Pierre, South Dakota [stamp] Give photo credit to: South Dakota State Historical Society.
Rapid City Journal
core   +1 more source

The Main Approaches to Economic Diagnostics of the Power Engineering Enterprises

Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2019
The features of economic diagnostics of power engineering enterprises in the Republic of Belarus are considered. Accounting and analysis of the activities of enterprises of the power system in the emerging energy market requires improving approaches of ...
T. F. Mantserova, D. A. Lapchenko
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Anaesthetic Mouthpiece Development through QFD and Customer Interaction with Functional Prototypes

, 2006
Published ArticleThe paper reflects on the development of a medical product using rapid prototyping technologies and customer interaction through a quality function deployment (QFD) approach to speed up the process, and to result in customer satisfaction.
Truscott, M., Booysen, G.J., Barnard, L.J., de Beer, D.J.   +3 more
core  

Implementing ideal health policy in a fragile health system: the example of expanding the use of malaria rapid diagnostic tests in mainland Tanzania. [PDF]

, 2011
Malaria confirmation before treatment provides an opportunity for improving the quality of malaria case management in endemic regions. However, increased coverage of this strategy is facing many organizational, logistical and technical challenges that ...
Jan Jacobs, de Bethune, Xavier, Masanja Irene M, Jacobs Jan, Irene M Masanja, Masanja, Irene M, Xavier de Bethune, de Bethune Xavier, Jacobs, Jan   +8 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Investigation of Sensitivity of Rapid Diagnosis Tests in Patients with Suspected Malaria

Objective: Malaria has been eradicated in Türkiye as of 2010, but there are imported cases. In this study, we aimed to compare the diagnostic value of two rapid tests; SD Bioline Malaria Ag Pf/Pan (SD-Pf/Pan) and SD Bioline Malaria Ag Pf/Pv (SD-Pf/Pv ...
Tuğba Kaya, Yusuf Önlen, Burcu Küçükeser, Mehmet Çabalak, Gülnaz Çulha   +4 more
core   +1 more source