Results 81 to 90 of about 4,824,315 (311)

Rapid diagnosis of lung infections

Nature Biotechnology, 2019
Nanopore sequencing of the sputum metagenome identifies respiratory pathogens in six hours.
Andrei Prodan, Morten O. A. Sommer, Max Nieuwdorp   +2 more
openaire   +3 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Rapid and Accurate Detection of Mycobacterium tuberculosis in Sputum Samples by Cepheid Xpert MTB/RIF Assay-A Clinical Validation Study [PDF]

, 2011
Background: A crucial impediment to global tuberculosis control is the lack of an accurate, rapid diagnostic test for detection of patients with active TB.
Perkins, M., Saathoff, E., Elmar Saathoff, Huggett, J, Zumla, A, Saathoff, E, Rojas-Ponce Gabriel, Andrea Rachow, Reither, K, Mtafya, Bariki, Huggett, J., Klaus Reither, Norbert Heinrich, Heinrich Norbert, Hoelscher Michael, Perkins Mark, Saathoff, Elmar, Mark Perkins, Mtafya, B, Boehme, C, Ntinginya, Elias N., Elias N. Ntinginya, O'Grady, J, Zumla Alimuddin, Saathoff Elmar, O'Grady, Justin, Catharina Boehme, Dheda, Keertan, Boehme Catharina, Ntinginya, EN, Dheda, K., Huggett Jim, Boehme, C., Rachow, A., Elias N Ntinginya, Jim Huggett, Dheda, K, Heinrich, N, Hoelscher, M., Keertan Dheda, Rojas-Ponce, G, Perkins, Mark, Hoelscher, Michael, Mtafya Bariki, Rachow, Andrea, Michael Hoelscher, Heinrich, N., Mtafya, B., Gabriel Rojas-Ponce, Rojas-Ponce, Gabriel, Boehme, Catharina, Perkins, M, Zumla, A., Reither, K., Rachow, A, Bariki Mtafya, Rojas-Ponce G.,, Reither, Klaus, Hoelscher, M, O'Grady J.,, Huggett, Jim, Ntinginya, E. N., O'Grady Justin, Heinrich, Norbert, Rachow Andrea, Reither Klaus, Zumla, Alimuddin, Dheda Keertan, Justin O'Grady, Ntinginya Elias N., Alimuddin Zumla   +70 more
core   +1 more source

Development and Evaluation of a MinION Full-Length 16S rDNA Sequencing Analysis Pipeline for Rapid Diagnosis of Animal Gastrointestinal Diseases

Microorganisms
Rapid and accurate detection of the causes of gastrointestinal diseases in farmed and companion animals is crucial for advancing livestock farming and safeguarding public health safety.
Ying Zhong, Qingyun Pan, Yu Wang, Jinyan Yu, Yaomen Li, Lifang Gu, Meicun Hou, Shenglong Liang, Jia Guo, Xinan Jiao, Yunzeng Zhang   +10 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Using RP to promote collaborative design of customised medical implants

, 2007
Published ArticleThe last decade has seen major advances in rapid prototyping (RP), with it becoming a multi‐disciplinary technology, crossing various research fields, and connecting continents.
Campbell, R. Ian, Truscott, Michèle, Barnard, Ludrick, Booysen, Gerrie, de Beer, Deon, Vicatos, George, Hosking, Keith   +6 more
core  

Determinants of the accuracy of rapid diagnostic tests in malaria case management: evidence from low and moderate transmission settings in the East African highlands. [PDF]

, 2008
BACKGROUND: The accuracy of malaria diagnosis has received renewed interest in recent years due to changes in treatment policies in favour of relatively high-cost artemisinin-based combination therapies.
Kristan, Mojca, Cox, Jonathan, Michael Okia, Jones Caroline, James Beard, Beard, James, Okia Michael, Caroline Jones, Jones, Caroline, Greenwood, Brian, Brian Greenwood, Rapuoda, Beth, Abeku Tarekegn A, Kristan Mojca, Cox Jonathan, Mojca Kristan, Mueller Dirk H, Dirk H Mueller, Greenwood Brian, Beth Rapuoda, Mueller, Dirk H, Tarekegn A Abeku, Rapuoda Beth, Jonathan Cox, Abeku, Tarekegn A, Okia, Michael, Beard James   +26 more
core   +1 more source

Comparison of chromogenic and cysteine lactose electrolyte deficient agar for identification of uropathogens in Gujarat, India

African Journal of Laboratory Medicine
Background: Urinary tract infections (UTIs) are prevalent bacterial infections, necessitating rapid and accurate diagnosis for timely treatment. Conventional culture techniques, such as cystine lactose electrolyte deficient (CLED) agar, can delay ...
Nisha Vadivelu, Rashmika D. Parmar, Hitesh Shingala, Krunal D. Mehta   +3 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source