Results 121 to 130 of about 837,711 (307)

Preferential access to genetic information from endogenous hominin ancient DNA and accurate quantitative SNP-typing via SPEX

, 2009
The analysis of targeted genetic loci from ancient, forensic and clinical samples is usually built upon polymerase chain reaction (PCR)-generated sequence data.
Endicott, Phillip, Sanchez, J., Cooper, Alan, Endicott, P., Brotherton, Paul, Sanchez, Juan J, Brotherton, P., Sanchez, Juan J., Cooper, A.   +8 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Confirmation of the presence of Mycobacterium-tuberculosis complex-specific DNA in three archaeological specimens

, 2002
This journal published the first reported identification of Mycobacterium tuberculosis complex (MTE) DNA in ancient human remains but CONCERNS were raised about the article two years after publication.
Spigelman, M, Matheson, C, Lev, G, Greenbaltt, C, Donoghue, HD   +4 more
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

A rapid screening for the specific DNA sequence: analysis of transforming DNA segments in adenovirus-transformed cells.

Gan, 1979
The viral DNA sequences in cells transformed by adenovirus type-12 (Ad12) DNA fragments were investigated by spot hybridization, a detection by autoradiography of nucleic acid hybrids formed between cell DNAs spotted on a membrane filter and various nick-translated Ad12 DNA fragments.
FUJINAGA, Kei, SAWADA, Yukiharu, UEMIZU, Yoshiko   +2 more
openaire   +2 more sources

Wolbachia and DNA barcoding insects: patterns, potential and problems

, 2012
Wolbachia is a genus of bacterial endosymbionts that impacts the breeding systems of their hosts. Wolbachia can confuse the patterns of mitochondrial variation, including DNA barcodes, because it influences the pathways through which mitochondria are ...
Janzen, D H, Mark R. Shaw (167095), Packer , L, Julie K. Stahlhut (167104), Claudia Bertrand (167052), Dirk Steinke, Xin Zhou, Crosby, K, Yanwei Li (167076), Quicke Donald, Quicke, D, Eveleigh Eldon S., Monty Wood, Steinke Dirk, Stahlhut, J K, Katharine Hind, Fernandez-Triana, J, Shaw, Mark R, Winnie Hallwachs, Hind Katharine, Ratnasingham, S, Da-Wei Huang, Yanwei, L, Katharine Hind (167065), Julie K Stahlhut, Bertrand, C, Eldon S. Eveleigh (167054), Hind, K, Daniel H Janzen, Jason Gibbs (167056), Brian L Fisher, Fisher, B L, Cory Sheffield, Mehrdad Hajibabaei, James Whitfield (167108), Monty Wood (167110), Miller Scott E., Josephine Rodriguez, Brian L. Fisher (47870), Sujeevan Ratnasingham (167085), Kate Crosby, Donald Quicke, Wood Monty, Janda Milan, Jan Hrcek (167068), Huang Da-Wei, Ratnasingham Sujeevan, Gibbs, J, Hallwachs Winnie, Huang, D W, Rodriguez, J J, Kate Crosby (167053), Laurence Packer, Scott E. Miller (167079), Eldon S Eveleigh, Smith M. Alex, James Whitfield, Zhou, X, Scott E Miller, Zhou Xin, Rodolphe Rougerie (134289), Yanwei Li, Janda, M, Crosby Kate, Hrcek, J, Cory Sheffield (167100), Whitfield, J B, Jason Gibbs, Wood, M, M Alex Smith, Rodolphe Rougerie, Smith, M A, Sheffield Cory, Rougerie Rodolphe, Hallwachs, W, Donald Quicke (167083), Fisher Brian L., Sheffield, C, Jan Hrcek, Rodriguez Josephine, Mehrdad Hajibabaei (76205), Packer Laurence, Stahlhut Julie K., Whitfield James, M. Alex Smith (47871), Winnie Hallwachs (167061), Wood , M, Milan Janda, Bertrand Claudia, Gibbs Jason, Da-Wei Huang (102802), Miller, S E, Dirk Steinke (15543), Laurence Packer (167080), Mark R Shaw, Li Yanwei, Packer, L, Hajibabaei Mehrdad, Rougerie, R, Claudia Bertrand, Hrcek Jan, Sujeevan Ratnasingham, Daniel H. Janzen (167074), Fernandez-Triana Jose, Steinke, D, Jose Fernandez-Triana (167055), Milan Janda (167072), Josephine Rodriguez (167090), Hajibabaei, M, Xin Zhou (54275), Jose Fernandez-Triana, Janzen Daniel H., Shaw Mark R., Eveleigh, E S, Janda , M   +114 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Rapid DNA Systems: An Analysis of Return on Investment (ROI) for Forensic Laboratories

Forensic Science International: Synergy, 2023
Max Houck, Paul Speaker
doaj   +1 more source

Spatiotemporal methylome remodeling during fiber differentiation in Gossypium hirsutum

BMC Genomics
Whole-genome methylome analysis reveals DNA methylation dynamics during upland cotton (Gossypium hirsutum) fiber development. DNA methylation levels initially increased and then decreased from -3 days post-anthesis (DPA) to 5 DPA, with a significant rise
Zhipeng Yu, Haijuan Cao, Xiaolian Xiong, Shuhan Wen, Xia Huang, Ying Jin, Junkang Rong, Mingquan Ding   +7 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source