Results 71 to 80 of about 837,711 (307)

Two new rapid SNP-typing methods for classifying Mycobacterium tuberculosis complex into the main phylogenetic lineages [PDF]

, 2012
There is increasing evidence that strain variation in Mycobacterium tuberculosis complex (MTBC) might influence the outcome of tuberculosis infection and disease.
Coscollà Mireia, David Stucki, Feldmann, Julia, Yeboah-Manu, D., Comas Iñaki, Gagneux, Sebastien, Hostettler Simon, Simon Hostettler, Thembela Huna (149818), Huna, Thembela, Huna Thembela, Malla Bijaya, Mireia Coscollà, Julia Feldmann (149820), Feldmann Julia, Stucki, David, Iñaki Comas (57109), Thembela Huna, Hostettler, S., Comas, Iñaki, Malla, Bijaya, Stucki David, Dorothy Yeboah-Manu, Sonia Borrell, David Stucki (149811), Huna, T., Gagneux, S., Yeboah-Manu, Dorothy, Fenner, Lukas, Borrell, Sonia, Dorothy Yeboah-Manu (120059), Comas, I., Bijaya Malla, Gagneux Sebastien, Fenner, L., Borrell Sonia, Hostettler, Simon, Lukas Fenner, Fenner Lukas, Bijaya Malla (149813), Sebastien Gagneux (149824), Mireia Coscollà (149823), Coscollà, Mireia, Sebastien Gagneux, Malla, B., Simon Hostettler (149816), Sonia Borrell (149821), Borrell, S., Julia Feldmann, Coscolla, M., Yeboah-Manu Dorothy, Lukas Fenner (149822), Iñaki Comas, Feldmann, J., Stucki, D.   +54 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Rapid metagenomics analysis of EMS vehicles for monitoring pathogen load using nanopore DNA sequencing.

PLoS ONE, 2019
Pathogen monitoring, detection and removal are essential to public health and outbreak management. Systems are in place for monitoring the microbial load of hospitals and public health facilities with strategies to mitigate pathogen spread.
Taylor Sheahan, Rhys Hakstol, Senthilkumar Kailasam, Graeme D Glaister, Andrew J Hudson, Hans-Joachim Wieden   +5 more
doaj   +1 more source

Acrylamide Capture of DNA-Bound Complexes: Electrophoretic Purification of Transcription Factors

BioTechniques, 2002
We have developed a rapid nonradioactive electrophoretic technique to analyze proteins within DNA-binding complexes, acrylamide capture of DNA-binding complexes (ACDC), using Acrydite™-linked DNA-binding targets. The method is highly sensitive and easily
Colleen Nelson, Stephen Hendy, Kim Reid, John Cavanagh   +3 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

An improved bind-n-seq strategy to determine protein-DNA interactions validated using the bacterial transcriptional regulator YipR

BMC Microbiology, 2020
Background Interactions between transcription factors and DNA lie at the centre of many biological processes including DNA recombination, replication, repair and transcription.
Shi-qi An, Miguel A. Valvano, Yan-hua Yu, Jeremy S. Webb, Guillermo Lopez Campos   +4 more
doaj   +1 more source

Analysis of mitochondrial DNA variation in the Egyptian population and its implications for forensic DNA analysis

, 2010
The genetic sequence of human mitochondrial DNA (mtDNA) is of particular interest to forensic investigations involving human identification, as well as population genetics.
Gomaa, R
core  

The white spot syndrome virus DNA genome sequence [PDF]

, 2001
White spot syndrome virus (WSSV) is at present a major scourge to worldwide shrimp cultivation. We have determined the entire sequence of the double-stranded, circular DNA genome of WSSV, which contains 292,967 nucleotides encompassing 184 major open ...
van Hulten, Mariëlle C W, Sandbrink, Hans, Vlak, Just M, Fiers, Mark, Lankhorst, René Klein, Vlak, Just M., Peters, Sander, van Hulten, Mariëlle C.W., Witteveldt, Jeroen, Tarchini, Renato, Kloosterboer, Nico, Lankhorst, Rene' K   +11 more
core   +1 more source