Results 51 to 60 of about 186,072 (301)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Response of Tropical Cyclone Formation and Intensification Rates to Climate Warming in Idealized Simulations

Journal of Advances in Modeling Earth Systems, 2020
There is currently no theory for the rate of tropical cyclone (TC) formation given a particular climate, so our understanding of the relationship between TC frequency and large‐scale environmental factors is largely empirical.
Hamish A. Ramsay, Martin S. Singh, Daniel R. Chavas   +2 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

More rapid intensification of flash droughts with shorter onset timescales [PDF]

, 2021
Abstract Flash droughts can cause more serious environmental and agricultural impacts than traditional droughts because of the sudden onset and rapid intensification. However, it remains unclear how rapidly flash droughts develop and intensify worldwide.
Yamin Qing, Shuo Wang, Brian C. Ancell, Zong-Liang Yang   +3 more
openaire   +1 more source

Diagnosis and typology of mountainous irrigated systems: Van Chan district, Yen Bai Province, Vietnam [PDF]

, 2009
L'histoire récente du Vietnam a été marquée par vingt dernières années de transition, passant d'une économie socialiste à une économie de marché. Dans le domaine agricole, les politiques récentes ont causés d'importants changements jusque dans des zones ...
Dang Dinh Quang,, Jamin, Jean-Yves, Jourdain, Damien, Rakotofiringa, Aurélie, Valony, Marie-Jeanne   +4 more
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Influence of global warming on the rapid intensification of western North Pacific tropical cyclones

Environmental Research Letters, 2019
The rapid intensification (RI) of tropical cyclones (TCs) associated with global warming is a matter of concern worldwide. This study examines how the RI across the western North Pacific is related to the so-called ‘efficiency of intensity’ (EINT ...
Nam-Young Kang, James B Elsner
doaj   +1 more source

Leveraging LSTM for rapid intensifications prediction of tropical cyclones [PDF]

ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2017
Abstract. Tropical cyclones (TCs) usually cause severe damages and destructions. TC intensity forecasting helps people prepare for the extreme weather and could save lives and properties. Rapid Intensifications (RI) of TCs are the major error sources of TC intensity forecasting. A large number of factors, such as sea surface temperature and wind shear,
Y. Li, R. Yang, C. Yang, M. Yu, F. Hu, Y. Jiang   +5 more
openaire   +3 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source