Results 111 to 120 of about 25,263,200 (250)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

In-hospital outcomes among older medical inpatients admitted to aged care wards after activation of a 2-tier rapid response system. [PDF]

BMC Geriatr, 2023
Basic D, Ní Chróinín D.
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Rapid Response System Escalation During Recovery of Hospital Bed Occupancy: An Observational Longitudinal Study. [PDF]

Nurs Crit Care
Noguchi A, Yamada T, Anzai T, Oka K, Ai M, Uchimura Y, Toba M, Takahashi K, Moriwaki M, Wakabayashi K.   +9 more
europepmc   +1 more source

We Are Not There Yet: A Qualitative System Probing Study of a Hospital Rapid Response System. [PDF]

J Patient Saf, 2022
Olsen SL, Søreide E, Hansen BS.
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Characteristics and Outcomes of Rapid Response System Activations in Obstetric Patients: A Multicenter Registry-Based Study in Japan. [PDF]

J Multidiscip Healthc
Nakai T, Tamura T, Tsuji T, Nakanishi T, Kamimura Y, Sento Y, Tanaka M, Sobue K.   +7 more
europepmc   +1 more source

Strategies for successful implementation and permanent maintenance of a rapid response system. [PDF]

Korean J Intern Med, 2021
Song MJ, Lee YJ.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Implementation of a Rapid Response System in a University Hospital: Impact on In-Hospital Mortality and Surgical Patient Outcomes. [PDF]

J Clin Med
Toma D, Bedreag OH, Andrei D, Păpurică M, Bârsac CR, Băloi A, Rogobete A, Ghenciu LA, Săndesc D.   +8 more
europepmc   +1 more source