Results 121 to 130 of about 25,263,200 (250)

Effect of Diurnal Variation of Heart Rate and Respiratory Rate on Activation of Rapid Response System and Clinical Outcome in Hospitalized Children. [PDF]

Children (Basel), 2023
Kim L, Yun KS, Park JD, Lee B.
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Understanding Pediatric Clinical Deterioration Through Rapid Response System Trigger Clusters. [PDF]

Hosp Pediatr
Piasecki RJ, Hunt EA, Perrin N, Spaulding EM, Winters B, Samuel L, Davidson PM, Chandra-Strobos N, Lasa JJ, Dennison-Himmelfarb CR, (for the American Heart Association’s Get With The Guidelines®-Resuscitation Investigators).   +10 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

A Realist Evaluation of a Rapid Response System for Mental State Deterioration in Acute Hospital Settings. [PDF]

J Adv Nurs
Dziruni TB, Hutchinson AM, Keppich-Arnold S, Bucknall T.   +3 more
europepmc   +1 more source

Implementation of a rapid response system at an isolated radiotherapy facility through simulation training. [PDF]

BMJ Open Qual, 2022
Kawamura H, Komatsu Y, Tanaka K, Kanamoto M, Tobe M, Usami C, Hinohara H, Oshima K, Kitada Y, Tsuda K, Ogano T, Shimada H, Ohno T.   +12 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Critique on Machine Learning Model for Predicting Short-Term Outcomes After Rapid Response System Activation. [PDF]

Acute Med Surg
Tahir H, Raza A.
europepmc   +1 more source

Impact of a standardised rapid response system on clinical outcomes of female patients: an interrupted time series approach. [PDF]

BMJ Open Qual, 2022
Chen J, Ou L, Hillman K, Parr M, Flabouris A, Green M.   +5 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source