Results 121 to 130 of about 38,509 (306)

DIRECT METAL LASER SINTERING, USING CONFORMAL COOLING, FOR HIGH VOLUME PRODUCTION TOOLING

South African Journal of Industrial Engineering, 2017
Existing techniques to manufacture conventional tool steel inserts for the plastic injection moulding process are expensive and time-consuming. Complex mould inserts, difficult to manufacture with conventional processes, can be produced using Direct ...
van As, Bertus , Combrinck, J. , Booysen, G. J. , De Beer, D. J.   +3 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Rapid casting and new technologies in investment casting

Ingeniería e Investigación, 2006
Rapid prototyping is a manufacturing process which is different to traditional methods as material is not removed or formed but added to obtain the designed pieces.
Claudia Marcela Sánchez R, Carlos Julio Cortés Rodríguez   +1 more
doaj  

The new helicopter composite duct manufacturing technology

Hangkong gongcheng jinzhan
In order to realize the high-quality，low-cost，agile and rapid manufacturing of AC332 civil helicopter composite duct structure，a new helicopter composite duct manufacturing technology is put forward by carrying out forward process design according to ...
QI Shutao
doaj   +1 more source

Additive manufacturing–assisted conformal cooling channels in mold manufacturing processes

Advances in Mechanical Engineering, 2017
This article aims to provide an overview of applications of rapid prototyping–assisted conformal cooling channel and shows the potential of this technology in different manufacturing processes.
Mahesh S Shinde, Kishor M Ashtankar
doaj   +1 more source

Перспективы использования генеративных технологий в двигателестроении [PDF]

, 2008
Рассмотрены перспективы использования генеративных технологий в двигателестроении. Определены тенденции интеграции Rapid Prototyping, Rapid Tooling и Rapid Manufacturing для скорейшего получения нового конечного продукта.
Грабченко, Анатолий Иванович, Доброскок, Владимир Ленинмирович, Фадеев, В. А., Чернышов, С. И.   +3 more
core  

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source