Results 41 to 50 of about 21,750 (299)
Advanced Science, EarlyView.This study elucidates how DCAF12 facilitates non‐degradative ubiquitination to stabilize TRiC/CCT, thereby enhancing the folding capacity of chaperonins. This mechanism promotes the maturation of cytoskeletal proteins and activates key oncogenic drivers, including YAP, STAT3, and mTOR, ultimately driving metastatic progression in lung cancer.
Zhenyi Wang +13 more
wiley +1 more source
PLoS ONE, 2014 PDK1 phosphorylates multiple substrates including Akt by PIP3-dependent mechanisms. In this report we provide evidence that in prostate cancer cells stimulated with activated α2-macroglobulin (α2M*) PDK1 phosphorylates Akt in the T-loop at Thr(308) by ...
Uma Kant Misra, Salvatore Vincent Pizzo
doaj +1 more source
Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2
eLife, 2022 The mTOR pathway is an essential regulator of cell growth and metabolism. Midbrain dopamine neurons are particularly sensitive to mTOR signaling status as activation or inhibition of mTOR alters their morphology and physiology.
Polina Kosillo +6 more
doaj +1 more source
Gaze‐Engineered 3D Augmented Reality
Advanced Intelligent Systems, EarlyView.Augmented Reality (AR) systems serve as a critical interface bridging users with the metaverse. This study explores the application of human factors engineering in metaverse development, specifically investigating the integration of eye‐tracking technology to enhance AR display performance.
Naiqin Zhao +3 more
wiley +1 more source
Status and Trends in the Eastern Imperial Eagle Population Between 1977 and 2018 in Slovakia
Пернатые хищники и их охрана, 2018 In Slovakia, two subpopulations of the Eastern Imperial Eagle (Aquila heliaca) – Western and Eastern Slovakian – are recognized with a distance between them of 200–300 km.
Jozef Chavko +5 more
doaj
Animals, 2022 The purpose of this retrospective study was to describe the causes of morbidity and mortality in free-ranging raptors admitted to a wildlife rehabilitation center (WRC) in Abruzzo Italy from 2005 to 2016 and the associated risk factors.
Ciro Cococcetta +5 more
doaj +1 more source
m6A Methylation‐Induced Autophagy Impairment by TFEB Regulation in SOD1‐G93A ALS Cell Model
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT We investigate the role of m6A RNA methylation in regulating transcription factor EB (TFEB) and its contribution to mitochondrial autophagy (mitophagy) dysfunction in amyotrophic lateral sclerosis (ALS). ALS cell models were used to analyse mitophagy markers and TFEB expression under METTL3 and TFEB modulation, using RT‐qPCR, Western blot ...
Di An +7 more
wiley +1 more source
The Bald And Golden Eagle Protection Act, Species-Based Legal Protection And The Danger Of Misidentification [PDF]
Potchefstroom Electronic Law Journal, 2015 The Bald and Golden Eagle Protection Act of 1940 bestows legal protection on two North American eagle species in the United States of America.
Johann C Knobel
doaj +1 more source
Arthritis &Rheumatology, Accepted Article.Objective The Phase 3 MANDARA study demonstrated non‐inferiority of benralizumab versus mepolizumab for remission in patients with eosinophilic granulomatosis with polyangiitis (EGPA). More benralizumab‐treated patients achieved complete withdrawal of oral glucocorticoids (OGCs).
Parameswaran K. Nair +14 more
wiley +1 more source
Пернатые хищники и их охрана, 2018 In 2005, five nestling Imperial Eagles (Aquila heliaca) were fitted with battery-powered GPS Satellite Transmitters (PTTs) in Slovakia to study their behaviour after fledging, two of them in the east and the other three in the west of the country.
Bernd-Ulrich Meyburg +4 more
doaj