Results 51 to 60 of about 1,597,634 (184)

Cystic Fibrosis and Colorectal Cancer Risk: Reprogramming of the Intestinal Epithelial Niche and Cell‐State Plasticity in the CFTR Modulator Era

Cell Proliferation, EarlyView.
In cystic fibrosis disorder, CFTR dysfunction drives multilayered intestinal niche disruption, including dysbiosis, inflammation, hypoxia, metabolic stress and genotoxic injury, promoting cell‐state plasticity and a pre‐neoplastic ecosystem. CFTR modulators and environmental factors may partially reshape these processes, highlighting opportunities for ...
Bala Umashankar, Ines Pankonien, Margarida Amaral, Chee Y. Ooi, Thierry Jardé, Shafagh A. Waters   +5 more
wiley   +1 more source

Microbiome and Metabolomics in Obesity: Advances in Understanding and Interventions Across the Lifespan

Obesity Reviews, EarlyView.
ABSTRACT Obesity arises from intertwined and reciprocal diet‐microbiome‐host pathways that reshape energy balance, insulin sensitivity, and inflammation. This review synthesizes mechanistic links between microbial functions and metabolic control, charts lifestyle‐related lifecourse dynamics from birth to older age, examines how GLP‐1‐based therapies ...
Ioanna Panagiota Kalafati, David Krongauz, Alice Bosco, Antonio Noto, Cristina Piras, Maria Kafyra, Angelica Dessì, Matteo Mauri, Luigi Atzori, Adina Weinberger, Vassilios Fanos, George V. Dedoussis, on behalf of the BETTER4U consortium   +12 more
wiley   +1 more source

PRODUCTION, PURIFICATION, AND CHARACTERIZATION OF BIOACTIVE METABOLITES PRODUCED FROM RARE ACTINOBACTERIA PSEUDONOCARDIA ALNI

Asian Journal of Pharmaceutical and Clinical Research, 2016
ABSTRACTObjectives: Pseudonocardia alni exhibits antimicrobial activity against tested pathogenic Staphylococcus aureus, Microsporum canis, and Trichophytonmentagrophyte. The present paper aimed to optimize various cultural conditions for antimicrobial metabolite production, purification, andcharacterization of the active substance.Methods: The effects
Rabab Omran Aljelawi, Mohammed Fadhil Kadhem   +1 more
openaire   +2 more sources

Exploring Actinobacteria Associated With Rhizosphere and Endosphere of the Native Alpine Medicinal Plant Leontopodium nivale Subspecies alpinum

Frontiers in Microbiology, 2019
The rhizosphere of plants is enriched in nutrients facilitating growth of microorganisms, some of which are recruited as endophytes. Endophytes, especially Actinobacteria, are known to produce a plethora of bioactive compounds.
Martina Oberhofer, Jaqueline Hess, Marlene Leutgeb, Florian Gössnitzer, Thomas Rattei, Christoph Wawrosch, Sergey B. Zotchev   +6 more
doaj   +1 more source

Fecal Microbiota Transplantation and Microbiota‐Based Therapeutics in Allogeneic Hematopoietic Stem Cell Transplantation: Current Evidence and Future Directions

Clinical Pharmacology &Therapeutics, Volume 120, Issue 4, Page 871-889, October 2026.
The intestinal microbiome is a key regulator of immune homeostasis, metabolism, and epithelial barrier integrity. In patients with malignant hematological diseases, particularly those undergoing hematopoietic stem cell transplantation, microbiome perturbations by reduced diversity, pathobiont expansion, and loss of beneficial metabolites are common as ...
Bálint Gergely Szabó, Dorina Korózs, Michal Bator, Krisztina Jeszenszky, Viktor Lakatos, László Gopcsa, Péter Reményi, János Sinkó   +7 more
wiley   +1 more source

Comparative Genome Mining of Jiangella sp. GA3 from Turtle-Ingested Plastic Reveals Conserved Biosynthetic Gene Clusters

Marine Drugs
Rare actinobacteria are promising sources of specialized metabolites, yet genome mining still prioritizes genomes encoding many biosynthetic gene clusters (BGCs) rather than clusters that are distant from characterized chemistry.
Ruggero Baviera, Fanny Claire Capri, Paola Galluzzo, Rosa Alduina   +3 more
doaj   +1 more source

Ineffectiveness of immune checkpoint inhibitors in prostate cancer: is it just a question of ‘‐mabs’?

The Journal of Pathology, Volume 270, Issue 2, Page 139-162, October 2026.
Abstract Prostate cancer (PCa) is the second most common type of neoplasm, currently treated with a variety of therapeutic agents. Although advances in treatment over the past decade have improved overall survival, patients with advanced PCa eventually progress from hormone‐sensitive PCa to metastatic castration‐resistant PCa.
Giuseppe Schepisi, Irene Torresan, Emilio Francesco Giunta, Sara Bleve, Nicole Brighi, Elisa Tassinari, Sofia Zanuccoli, Maria Concetta Cursano, Cristian Lolli   +8 more
wiley   +1 more source

Diversity and antimicrobial activity of culturable actinobacteria isolated from the sediment of Sarıkum Lake

Biotechnology & Biotechnological Equipment, 2021
In this study, actinobacteria isolated from Sarıkum Lake sediment were characterized (Sinop-Turkey). A total of 48 actinobacteria were isolated using ten selective media with the dilution-plating method.
Aysel Veyisoglu, Demet Tatar
doaj   +1 more source

The Chaetocerosphere: Chaetoceros Species and Associated Prokaryotes in a Coastal Area

Environmental Microbiology Reports, Volume 18, Issue 5, October 2026.
Chaetoceros species maintain recurrent distinct prokaryotic assemblages in their phycosphere. Alphaproteobacteria, Bacteroidetes and Archaea Thermoplasmata and Marine Group II are the most represented in the phycosphere. Bipartite networks highlight strong links between the diatom and specific prokaryotic taxa, especially the chain‐forming species ...
Anna Chiara Trano, Raffaella Casotti, Roberta Piredda   +2 more
wiley   +1 more source

Marine Rare Actinomycetes: A Promising Source of Structurally Diverse and Unique Novel Natural Products

Marine Drugs, 2019
Rare actinomycetes are prolific in the marine environment; however, knowledge about their diversity, distribution and biochemistry is limited. Marine rare actinomycetes represent a rather untapped source of chemically diverse secondary metabolites and ...
Ramesh Subramani, Detmer Sipkema
doaj   +1 more source