Results 61 to 70 of about 1,107,549 (295)

KITD816V+ systemic mastocytosis associated with KITD816V+ acute erythroid leukaemia: first case report with molecular evidence for same progenitor cell derivation [PDF]

, 2009
Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE ...
H-P Horny, K K Reichard, K Sotlar, M K Foucar, S A McClintock-Treep   +4 more
core   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Quantitative analysis of cell types during growth and morphogenesis in Hydra [PDF]

, 1973
Tissue maceration was used to determine the absolute number and the distribution of cell types in Hydra. It was shown that the total number of cells per animal as well as the distribution of cells vary depending on temperature, feeding conditions, and ...
A. Gierer, A. L. Burnett, C. N. David, C. N. David, E. Trenkner, G. Webster, H. Bode, H. K. MacWilliams, H. Schaller, J. J. Kanaev, L. Wolpert, P. Tardent, P. Tardent, R. D. Campbell, S. Berking, T. L. Lentz, W. F. Loomis   +16 more
core   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

PRIMARY ENEROPATHY-ASSOCIATED T-CELL EXTRNODAL LYMPHOMA DEBUTING WITH COMPLICATIONS. ANALYSIS OF TWO CASE REPORTS AND THE REASONS FOR THEIR UNFAVORABLE OUTCOME

Сибирский онкологический журнал, 2021
Background. T-cell lymphoma with small and/or large bowel perforation is classified as a rare and extremely aggressive malignant non-Hodgkin’s lymphoma (NHL).
A. Z. Almyashev, R. A. Ulyankina, P. I. Skopin, A. A. Ivashin, A. A. Mokhammed   +4 more
doaj   +1 more source

Mitotic antipairing of homologous and sex chromosomes via spatial restriction of two haploid sets. [PDF]

, 2018
Pairing homologous chromosomes is required for recombination. However, in nonmeiotic stages it can lead to detrimental consequences, such as allelic misregulation and genome instability, and is rare in human somatic cells.
Hua, Lisa L, Mikawa, Takashi
core   +1 more source

Challenges in identifying cancer genes by analysis of exome sequencing data. [PDF]

, 2016
Massively parallel sequencing has permitted an unprecedented examination of the cancer exome, leading to predictions that all genes important to cancer will soon be identified by genetic analysis of tumours.
Bandyopadhyay, Sourav, Carter, Hannah, Friend, Stephen, Hofree, Matan, Ideker, Trey, Kreisberg, Jason F, Mischel, Paul S   +6 more
core   +1 more source

The Fate (Outcome) of Clinically Apparent Single Lesion and Oligofocal Nephroblastomatosis Treated According to SIOP/GPOH Protocols for Wilms Tumor

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The management of clinically apparent single lesions or oligofocal nephroblastomatosis, a facultative precursor of nephroblastoma, remains debated. Methods We retrospectively analyzed 37 patients with clinically apparent single or oligofocal nephroblastomatosis (two to three lesions per kidney) among 2347 patients registered between
Nils Welter, Jens‐Peter Schenk, Jenny Wegert, Manfred Gessler, Leo Kager, Stefan Wagenpfeil, Marina Müller, Jean‐Michel Wolff, Joerg Fuchs, Steven W. Warmann, Clemens‐Magnus Meier, Jochen Hubertus, Christian Rübe, Christian Vokuhl, Patrick Melchior, Lena Tschirner, Norbert Graf, Rhoikos Furtwängler   +17 more
wiley   +1 more source

Computational cytometer based on magnetically modulated coherent imaging and deep learning. [PDF]

, 2019
Detecting rare cells within blood has numerous applications in disease diagnostics. Existing rare cell detection techniques are typically hindered by their high cost and low throughput.
Bai, Bijie, Ceylan Koydemir, Hatice, Cheung, Chloe, Di Carlo, Dino, Duan, Zhuoran, Feizi, Alborz, Garner, Omai B, Guziak, Alexander, Kim, Danny, Kim, Donghyuk, Kong, Janay, Liu, Tairan, Liu, Xuewei, Luo, Yi, Ouyang, Mengxing, Ozcan, Aydogan, Ray, Aniruddha, Tsai, Katherine, Yalcin, Sener, Zhang, Yibo   +19 more
core  

Mime-seq 2.0: a method to sequence microRNAs from specific mouse cell types

The EMBO Journal
Many microRNAs (miRNAs) are expressed with high spatiotemporal specificity during organismal development, with some being limited to rare cell types, often embedded in complex tissues.
Ariane Mandlbauer, Qiong Sun, Niko Popitsch, Tanja Schwickert, Miroslava Spanova, Jingkui Wang, Stefan L Ameres, Meinrad Busslinger, Luisa Cochella   +8 more
doaj   +1 more source