Results 201 to 210 of about 97,259 (285)

Exocrine Gland Dysfunction in Parkinson's Disease: Pathophysiology, Clinical Manifestations, and Therapeutic Perspectives—A Narrative Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Non‐motor symptoms, especially autonomic dysfunction, are major contributors to disability and decreased quality of life in Parkinson's disease (PD). Despite being common and having a wide range of clinical facets, exocrine gland dysfunction is still not well recognized and managed.
Renato P. Munhoz, Marina Farah, Laura Silveira‐Moriyama   +2 more
wiley   +1 more source

RNAprecis: Prediction of full-detail RNA conformation from the experimentally best-observed sparse parameters. [PDF]

PLoS Comput Biol
Wiechers H, Williams CJ, Eltzner B, Hoppe F, Prisant MG, Chen VB, Miller E, Mardia KV, Richardson JS, Huckemann SF.   +9 more
europepmc   +1 more source

High‐Fat Diet Exacerbates Neuropathology in a Transgenic Mouse Model of Multiple System Atrophy

Movement Disorders, EarlyView.
Abstract Background Multiple system atrophy (MSA) is a rare and devastating neurodegenerative disorder. Accumulating clinical and preclinical evidence suggests that diabetes and insulin resistance may adversely influence MSA pathophysiology. Objective We investigated the potential association between diabetes, impaired glucose homeostasis, and MSA ...
Marie‐Laure Arotcarena, Anna Delamarre, Miguel Lopez‐Cuina, Hugo Martin, Elio Balpe, Xavier Fioramonti, Erwan Bezard, Wassilios G. Meissner   +7 more
wiley   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Pd-catalyzed stereoretentive synthesis of reversed <i>C</i>-acyl glycosides: access to rare l-sugars and higher-carbon sugars. [PDF]

Chem Sci
Cheng G, Yang B, Zhu F.
europepmc   +1 more source

The rare sugar D-allose acts as a triggering molecule of rice defence via ROS generation. [PDF]

J Exp Bot, 2013
Kano A, Fukumoto T, Ohtani K, Yoshihara A, Ohara T, Tajima S, Izumori K, Tanaka K, Ohkouchi T, Ishida Y, Nishizawa Y, Ichimura K, Tada Y, Gomi K, Akimitsu K.   +14 more
europepmc   +1 more source

Rare Sugar Production through Isomerization of Reducing Sugars in Subcritical Fluids

Japan Journal of Food Engineering
Takashi KOBAYASHI, Pramote KHUWIJITJARU, Khwanjai KLINCHONGKON, Shuji ADACHI, Yoshiyuki WATANABE   +4 more
openaire   +1 more source

Review of Congenital Myasthenic Syndrome Caused by Pathogenic Variants in GFPT1

Muscle &Nerve, EarlyView.
ABSTRACT Glutamine:fructose‐6‐phosphate transaminase 1 (GFPT1) catalyzes the first and rate‐limiting step of the hexosamine biosynthetic pathway (HBP) to generate UDP‐GlcNAc. GFPT1 exon 9 is specifically spliced in in striated muscles, which makes a long isoform of GFPT1 (GFPT1‐L).
Kinji Ohno, Mohammad Nazim, Ruchen Zhang, Paniz Farshadyeganeh, Mikako Ito, Bisei Ohkawara   +5 more
wiley   +1 more source

Engineering of <i>Escherichia coli</i> for D-tagatose production from lactose and whey permeate via the tagatose-6-phosphate pathway. [PDF]

Curr Res Food Sci
Abzach A, Ben-Adiva R, Gruzdev N, Musa S, Yadid I.   +4 more
europepmc   +1 more source