Results 61 to 70 of about 3,077,819 (277)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Lost in the Vaso‐Occlusion: A Patient's Abdominal Pain Returns With a Vengeance

Pediatric Blood &Cancer, EarlyView.
Dunia Hatabah, Martha E. Stewart, Nathan Maassel, James P. Stevens, Claudia R. Morris, Chris A. Rees   +5 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Rarefied Nozzle Flow Computation Using the Viscosity-Based Direct Simulation Monte Carlo Method

Fluids
Micro-nozzles are essential for enabling precise satellite attitude control and orbital maneuvers. Accurate prediction of performance parameters, including thrust and specific impulse, is critical, necessitating careful design of these nozzles. Given the
Deepa Raj Mopuru, Nishanth Dongari, Srihari Payyavula   +2 more
doaj   +1 more source

Rarefied dynamic pressure distribution measurement near a vacuum pump

Nihon Kikai Gakkai ronbunshu, 2020
In vacuum chambers, such as those at a ground test facility, pressure is higher and the gas resident time is longer than in space because such chambers are surrounded by walls and vacuum pumps.
Yoshinori NAKAYAMA
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Numerical simulation of aerodynamic characteristics during rarefied atmospheric braking

Kongqi donglixue xuebao
Aerodynamic characteristics in rarefied atmospheric environments are one of the key factors influencing the high-altitude aerodynamic braking of orbiters.
Ziwei Li, Yuzhu Yao, Qi Li, Xuefeng Wang, Fei Huang, Xiaoli Cheng   +5 more
doaj   +3 more sources

Higher-order Knudsen's permeability correction model for rarefied gas in micro-scale channels

Natural Gas Industry B, 2019
Rarefaction effect appears when gas flows in micro/nano channels, so it is difficult to accurately predict real gas flow rate by using the classical theory.
Yinbin Lu
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Drag characteristics of micron-sized tungsten dust in high-Mach rarefied flow during in-vessel LOCA of fusion reactor with Maxwell slip/DSMC hybrid modeling

Nuclear Fusion
In a fusion reactor, an in-vessel loss of coolant accident (LOCA) involving the helium-cooled blanket will lead to the resuspension and migration of tritiated and micron-sized tungsten dust deposited at the bottom of the vacuum vessel under high-speed ...
Zhijie Qin, Shichao Zhang, Zhen Wang, Zhibin Chen, Jiangtao Jia, Taosheng Li   +5 more
doaj   +1 more source