Results 31 to 40 of about 3,764 (258)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
FluidsNumerical modeling of gas flows in rarefied regimes is crucial in understanding fluid behavior in microscale applications. Rarefied regimes are characterized by a decrease in molecular collisions, and they lead to unusual phenomena such as gas phase ...
Michel Ho +5 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Multiscale simulation of interacting turbulent and rarefied gas flows in the DSMC framework
Theoretical and Applied Mechanics LettersA multiscale stochastic-deterministic coupling method is proposed to investigate the complex interactions between turbulent and rarefied gas flows within a unified framework.
Liyan Luo, Songyan Tian, Lei Wu
doaj +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Aerodynamic optimization of NACA 0012 airfoils with attached Gurney flap in the rarefied gas flow
AIP Advances, 2023 The aerodynamic optimization of a Gurney flap attached to the NACA 0012 airfoil in rarefied gas flow is studied in this study. In order to investigate the effects of Gurney flap geometry (height, mounting angle, and mounting location) and angle of attack
Keren Lin +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Effect of viscosity on slip boundary conditions in rarefied gas flows
Vietnam Journal of Mechanics, 2019 The viscosity of gases plays an important role in the kinetic theory of gases and in the continuum-fluid modeling of the rarefied gas flows. In this paper we investigate the effect of the gas viscosity on the surface properties as surface gas ...
Nam T. P. Le
doaj +1 more source
Inverse Magnus Effect in a Rarefied Gas
, 2023 AbstractThe transverse force exerted on a rotating sphere immersed in an otherwise uniform flow of a rarefied gas is investigated based on the Bhatnagar–Gross–Krook (BGK) model of the Boltzmann equation assuming the Maxwell boundary condition on the sphere.
Taguchi, Satoshi, Tsuji, Tetsuro
openaire +2 more sources
A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline
FEBS Open Bio, EarlyView.Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey +4 more
wiley +1 more source