Results 51 to 60 of about 25,025 (293)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Experimental Study on Gas Flow in a Rough Microchannel

Frontiers in Energy Research, 2022
The shape and relative roughness of a rough surface have an important influence on microscale flow and heat transfer. In this study, a rectangular silicon microchannel (0.8 mm width and 11.9 μm height) with a large width-depth ratio is fabricated by the ...
Deming Li, Ruixue Yang, Hui Cao, Feng Yao, Chaoqun Shen, Chengbin Zhang, Suchen Wu   +6 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Highly rarefied gas flows in rough channels of finite length

Advances in Aerodynamics, 2023
Highly rarefied gas flows through a rough channel of finite length with small bumps appended to its surfaces are investigated, by varying the accommodation coefficient $$\alpha$$ α in Maxwell’s diffuse-specular boundary condition, the characteristic size
Zheng Shi, Yulong Zhao, Wei Su, Lei Wu
doaj   +1 more source

DSMC Simulation of the Effect of Needle Valve Opening Ratio on the Rarefied Gas Flows inside a Micronozzle with a Large Length-to-Diameter Ratio

Aerospace, 2023
The cold gas micro-propulsion system can provide low noise and ultra-high accuracy thrust for satellite platforms for space gravitational wave detection, high-precision earth gravity field measurement.
Xudong Wang, Yong Li, Yong Gao, Chenguang Gao, Weichun Fu   +4 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

DSMC investigation of rarefied gas flow through diverging micro- and nanochannels

, 2017
Direct simulation Monte Carlo (DSMC) method with simplified Bernoulli-trials (SBT) collision scheme has been used to study the rarefied pressure-driven nitrogen flow through diverging microchannels.
Ebrahimi, Amin, Roohi, Ehsan
core   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Investigation on the Opposing Jet in the Hypersonic Rarefied Flow over a Vehicle Based on the DSMC Method

Actuators, 2022
In this paper, an opposing jet is applied to the space shuttle arc leading edge and the lifting body cone leading edge in the hypersonic condition of the rarefied flow field.
Yi Shen, Jun Zhang, Xiao Xu, Jing Liu, Zhaoming Zhang, Yanmei Jiao   +5 more
doaj   +1 more source

Piecewise continuous partition function method in the theory of wave perturbations of inhomogeneous gas

, 2004
The problem of wave disturbance propagation in rarefied gas in gravity field is explored. The system of hydrodynamic-type equations for a stratified gas in gravity field is derived from BGK equation by method of piecewise continuous partition function ...
Alexeev, Alexeev, Alexeev, Buckner, Cercignani, Chapman, Chen, Chen, D.A. Vereshchagin, Greenspan, Gross, Ivchenko, Kostomarov, Leble, Leble, Lees, Liu, Loyalka, M.A. Solovchuk, Meyer, Mott-Smith, S.B. Leble, Sampson, Shidlovskij, Sirovich, Spiegel, Vereshchagin, Vereshchagin   +27 more
core   +1 more source