Results 11 to 20 of about 499,302 (317)

Ras-GRF Activates Ha-Ras, but Not N-Ras or K-Ras 4B, Proteinin Vivo [PDF]

Journal of Biological Chemistry, 1998
Human cells contain four homologous Ras proteins, but it is unknown whether these homologues have different biological functions. As a first step in determining if Ras homologues might participate in distinct signaling cascades, we assessed whether a given Ras guanine nucleotide exchange factor could selectively activate a single Ras homologue in vivo.
M K, Jones, J H, Jackson
openaire   +2 more sources

While K-ras is essential for mouse development, expression of the K-ras 4A splice variant is dispensable [PDF]

, 2003
In mammals, the three classical ras genes encode four highly homologous proteins, N-Ras, H-Ras, and the isoforms K-Ras 4A and 4B. Previous studies have shown that K-ras is essential for mouse development and that while K-ras 4A and 4B are expressed ...
Patek, C. E., Ann-Marie Ritchie, Melton, D. W., Doig, Jennifer, Arends, Mark J, D James Williamson, Charles E Patek, Arends, M. J., Ritchie, A. M., Plowman, Sarah J, Williamson, D James, Maureen J O'sullivan, Ritchie, Ann-Marie, Melton, David W, Sarah J Plowman, Hooper, Martin L, David W Melton, Harrison, David J, Arends, Mark J; id_orcid, O'Sullivan, M. J., Harrison, D. J., Hooper, M. L., Plowman, S. J., David J Harrison, O'Sullivan, Maureen J, Jennifer Doig, Doig, J., Martin L Hooper, Patek, Charles E, Mark J Arends, Williamson, D. J.   +30 more
core   +1 more source

Apparent nutrient utilization and metabolic growth rate of Nile tilapia, Oreochromis niloticus, cultured in recirculating aquaculture and biofloc systems

Open Agriculture, 2022
Recirculating aquaculture systems (RAS) and biofloc systems (BFS) have been considered eco-friendly aquaculture technologies in the last few decades. However, which system performs better has become a common question for fish farmers.
Amin Muhamad, Agustono Agustono, Ali Muhamad, Prayugo Prayugo, Hum Nurul Nadiah Mohd Firdaus   +4 more
doaj   +1 more source

K-Ras mediated murine epidermal tumorigenesis Is dependent upon and associated with elevated Rac1 activity [PDF]

, 2011
A common goal for potential cancer therapies is the identification of differences in protein expression or activity that would allow for the selective targeting of tumor vs. normal cells. The Ras proto-oncogene family (K-Ras, H-Ras and N-Ras) are amongst
Samuel, M., Lourenco, F., Michael S Samuel, Filipe C Lourenço, Olson, M.F., Michael F Olson, Filipe C. Lourenço, Samuel Michael S., Olson Michael F., Samuel, M.S., Lourenço, F.C., Michael S. Samuel, Lourenço Filipe C., Olson, M., Michael F. Olson   +14 more
core   +1 more source

Ras Binding Triggers Ubiquitination of the Ras Exchange Factor Ras-GRF2 [PDF]

Molecular and Cellular Biology, 2001
Ras is a small GTPase that is activated by upstream guanine nucleotide exchange factors, one of which is Ras-GRF2. GRF2 is a widely expressed protein with several recognizable sequence motifs, including a Ras exchanger motif (REM), a PEST region containing a destruction box (DB), and a Cdc25 domain.
C L, de Hoog, J A, Koehler, M D, Goldstein, P, Taylor, D, Figeys, M F, Moran   +5 more
openaire   +2 more sources

Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2 [PDF]

, 1996
The Ras oncogene products regulate the expression of genes in transformed cells, and members of the Ets family of transcription factors have been implicated in this process.
Yang, Beom-Seok, Ostrowski, M C, Hauser, C A, Hauser, Craig A., Van Beveren, Charles, Maki, R A, Yang, B S, Henkel, G, Hume, D A, Ostrowski, Michael C., Colman, M S, Colman, Michael S., Van Beveren, C, Henkel, Gregory, Stacey, K J, Hume, David A., Maki, Richard A., Stacey, Katryn J.   +17 more
core   +1 more source

Acquisition of Anoikis Resistance Promotes the Emergence of Oncogenic K-ras Mutations in Colorectal Cancer Cells and Stimulates Their Tumorigenicity In Vivo

Neoplasia: An International Journal for Oncology Research, 2007
Detachment from the extracellular matrix causes apoptosis of normal epithelial cells—a phenomenon called anoikis. K-ras oncogene, an established anoikis inhibitor, often occurs in colorectal carcinoma (CRC).
Mathieu Derouet, Xue Wu, Linda May, Byong Hoon Yoo, Takehiko Sasazuki, Senji Shirasawa, Janusz Rake, Kirill V. Rosen   +7 more
doaj   +1 more source

Mitt namn är Shaft

Sociologisk Forskning, 2020
Filmkaraktären Shaft har tagit form under olika perioder av politisk polarisering i det amerikanska samhället. Syftet med denna artikel är att närmare undersöka hur karaktären Shaft har porträtteras i tre filmer från olika tidsperioder.
Peter Ehrström, Magnus Dahlstedt
doaj   +1 more source

K-ras and p53 mutations in colonic lavage fluid of patients with colorectal neoplasias [PDF]

, 2001
Background: The adenoma-carcinoma sequence has its molecular basis in several gene mutations of which K-ras and p53 are of paramount importance. The aims of this study were to evaluate whether these genetic alterations can be detected in colonic lavage ...
Folwaczny, Christian, Heinzlmann, M., Neynaber, S., Heldwein, W.   +3 more
core   +1 more source

An architecture for supporting RAS on Linux-based IoT gateways [PDF]

, 2017
With the rapid advances in IoT technologies, the role of IoT gateways becomes even more important. Therefore, improving the reliability, availability and serviceability (RAS) of IoT gateways is crucial.
Cu Pham, Tan Le, Yuto Lim, Tan, Yasuo, Pham, Cu, Le, Tan, Yasuo Tan, Lim, Yuto   +7 more
core   +1 more source