Results 31 to 40 of about 1,474,638 (301)

Angiotensin-(1-7) and angiotensin-(1-9): function in cardiac and vascular remodeling [PDF]

, 2014
The renin angiotensin system (RAS) is integral to cardiovascular physiology, however, dysregulation of this system largely contributes to the pathophysiology of cardiovascular disease (CVD).
Akishita, Barroso, Booz, Bosnyak, Bosnyak, Brosnihan, Bruneval, Bryan, Calo, Campbell, Caroline Fattah, Castro, Chappell, Chappell, Chen, Christopher M. Loughrey, Clare A. McKinney, Clarke, Costa, Crackower, Cushman, De Mello, Dias-Peixoto, Domeier, Dong, Donoghue, Donoghue, Drummer, Faria-Silva, Ferreira, Ferreira, Ferreira, Ferreira, Flores-Munoz, Flores-Munoz, Fomovsky, Fraga-Silva, Fraga-Silva, Freeman, Galis, Gava, Gembardt, Gomes, Graeme Milligan, Grobe, Gusev, Hanke, Hannan, Harmer, Heitsch, Horiguchi, Horiuchi, Hunyady, Inaba, Iwata, Jackman, Jaiswal, Jarajapu, Kaminska, Kassiri, Katada, Kokkonen, Kramkowski, Langeveld, Lautner, Liao, Libby, Liu, Loot, Lovren, Masson, McCollum, Mehta, Mercure, Miura, Mogielnicki, Nakajima, Newby, Ng, Nouet, Ocaranza, Ocaranza, Ocaranza, Patel, Patel, Qi, Ray, Rice, Rodgers, Rodrigues-Machado, Ross, Rowe, Sampaio, Sampaio, Santos, Santos, Schultz Jel, Selvetella, Shah, Sheng-Long, Singh, Sluimer, Stegbauer, Strawn, Stuart A. Nicklin, Tallant, Tesanovic, Tipnis, Turner, Uekama, Varagic, Vickers, Vilas-Boas, Walters, Wang, Weber, West, Wiemer, Yamada, Yang, Zeng, Zhang, Zhao, Zhong   +123 more
core   +1 more source

Ras Binding Triggers Ubiquitination of the Ras Exchange Factor Ras-GRF2 [PDF]

Molecular and Cellular Biology, 2001
Ras is a small GTPase that is activated by upstream guanine nucleotide exchange factors, one of which is Ras-GRF2. GRF2 is a widely expressed protein with several recognizable sequence motifs, including a Ras exchanger motif (REM), a PEST region containing a destruction box (DB), and a Cdc25 domain.
C L, de Hoog, J A, Koehler, M D, Goldstein, P, Taylor, D, Figeys, M F, Moran   +5 more
openaire   +2 more sources

Rubber agroforestry systems in mature plantations in Phatthalung Province, Southern Thailand [PDF]

, 2020
Rubber-based agroforestry systems (RAS) can be characterized by the type of trees/shrubs and crops associated with the rubber trees. The present study objective was to identify and describe the RAS in mature plantations existing in Phatthalung province ...
Chambon, Bénédicte, Penot, Eric, Tongkaemkaew, Uraiwan   +2 more
core  

Importance and applications of robotic and autonomous systems (RAS) in railway maintenance sector: a review [PDF]

, 2019
Maintenance, which is critical for safe, reliable, quality, and cost-effective service, plays a dominant role in the railway industry. Therefore, this paper examines the importance and applications of Robotic and Autonomous Systems (RAS) in railway ...
Ackerman, Guler, Li, McNulty, Márquez, Reason, Smorenburg   +6 more
core   +3 more sources

Effect of addition of mineral salts to recirculating aquaculture system: evaluation of water quality, growth performance and some biochemical and immune indices of African cichlid (Labidochromis lividus) fish [PDF]

بوم‌شناسی آبزیان, 2022
In the present study, the effects of startup and addition of ammonium chloride (NH4Cl) and sodium nitrite (NaNO2) salts for 4 weeks before fish stocking on efficiency of biofilter for removal of total ammonia nitrogen (TAN) from water, survival rate ...
Mehrdad Sarkheil, Omid Safari, Saeed Zahedi   +2 more
doaj  

RAS and beyond: the many faces of the neurofibromatosis type 1 protein

Disease Models & Mechanisms, 2022
Neurofibromatosis type 1 is a rare neurogenetic syndrome, characterized by pigmentary abnormalities, learning and social deficits, and a predisposition for benign and malignant tumor formation caused by germline mutations in the NF1 gene.
Corina Anastasaki, Paola Orozco, David H. Gutmann   +2 more
doaj   +1 more source

Dynamic regulation of RAS and RAS signaling

Biochemical Journal, 2023
RAS proteins regulate most aspects of cellular physiology. They are mutated in 30% of human cancers and 4% of developmental disorders termed Rasopathies. They cycle between active GTP-bound and inactive GDP-bound states. When active, they can interact with a wide range of effectors that control fundamental biochemical and biological processes. Emerging
Walter Kolch, Dénes Berta, Edina Rosta
openaire   +3 more sources

Farnesylthiosalicylic Acid-Loaded Albumin Nanoparticle Alleviates Renal Fibrosis by Inhibiting Ras/Raf1/p38 Signaling Pathway

International Journal of Nanomedicine, 2021
Hui Huang,1,2 Qinhui Liu,1 Ting Zhang,2 Jinhang Zhang,1,2 Jian Zhou,1,2 Xiandan Jing,2 Qin Tang,1 Cuiyuan Huang,1,2 Zijing Zhang,1 Yingnan Zhao,1,2 Guorong Zhang,1,2 Jiamin Yan,1,2 Yan Xia,1,2 Ying Xu,1,2 Jiahui Li,1,2 Yanping Li,1 Jinhan He1,2 ...
Huang H, Liu Q, Zhang T, Zhang J, Zhou J, Jing X, Tang Q, Huang C, Zhang Z, Zhao Y, Zhang G, Yan J, Xia Y, Xu Y, Li J, Li Y, He J   +16 more
doaj  

RAS-mediated tumor stress adaptation and the targeting opportunities it presents

Disease Models & Mechanisms, 2022
Cellular stress is known to function in synergistic cooperation with oncogenic mutations during tumorigenesis to drive cancer progression. Oncogenic RAS is a strong inducer of a variety of pro-tumorigenic cellular stresses, and also enhances the ability ...
Alexandra Redding, Andrew E. Aplin, Elda Grabocka   +2 more
doaj   +1 more source

Assignments of backbone 1H, 13C and 15N resonances in H-Ras (1–166) complexed with GppNHp at physiological pH [PDF]

, 2012
The small GTPase Ras is an important signaling molecule acting as a molecular switch in eukaryotic cells. Recent findings of global conformational exchange and a putative allosteric binding site in the G domain of Ras opened an avenue to understanding ...
Kovriguine, Evgueni, O\u27Connor, Casey
core   +1 more source