Results 51 to 60 of about 499,302 (317)

An increase in N-Ras expression is associated with development of hormone refractory prostate cancer in a subset of patients [PDF]

, 2008
Protein expression of H, K and N-Ras was assessed in hormone sensitive and hormone refractory prostate tumour pairs from 61 patients by immunohistochemistry. Expression of H-Ras and K- Ras was not associated with any known clinical parameters.
Traynor, P., McGlynn, L.M., Mukherjee, R., Grimsley, S.L.S., Bartlett, J.M.S., Edwards, J.   +5 more
core  

Promotion of cancer cell stemness by Ras [PDF]

, 2021
peer reviewedCancer stem cells (CSC) may be the most relevant and elusive cancer cell population, as they have the exquisite ability to seed new tumors.
CHIPPALKATTI, Rohan, ABANKWA, Daniel
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Pathway to RAS [PDF]

Genetics, 2006
When I started my laboratory at Caltech in 1987, I hung on my door a wall chart from Oncogene Sciences with all the known proto-oncogenes and their cellular locations and regulatory relationships. One of these, ras, was identified by viral and cancer genetics as a dominant oncogene in many tumors and in transforming retroviruses.
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

RAS-effector interaction hotspots.

, 2016
(A) Interaction matrix of RAS isoforms and effector proteins. Interaction matrix is launched to demonstrate interaction residues in all available structures (see Fig 3 and S4 Fig).
Mohammad Reza Ahmadian (596739), Hossein Nakhaeizadeh (3390107), Ehsan Amin (832281), Radovan Dvorsky (832280), Saeideh Nakhaei-Rad (3390110)   +4 more
core   +1 more source

Ras signalling in pathogenic yeasts [PDF]

, 2017
The small GTPase Ras acts as a master regulator of growth, stress response and cell death in eukaryotic cells. The control of Ras activity is fundamental, as highlighted by the oncogenic properties of constitutive forms of Ras proteins.
Campbell W. Gourlay, Mühlschlegel, Fritz A., Piper-Brown, Elliot, Gourlay, Campbell W., Pentland, Daniel R, Fritz A. Mühlschlegel, Daniel R. Pentland, Elliot Piper-Brown, Fritz A. Muehlschlegel   +8 more
core   +1 more source

Verification of the responses of activated kinases to Ras in the composed EGFR-Ras-MAPK bond graph model by comparing with the predicted steady-state responses in the MAPK cascade module.

, 2022
(A) Ultrasensitivity in the composed EGFR-Ras-MAPK bond graph model. The steady-state concentrations of the kinases are: MKKKP = 1.37 nM, MKKPP = 1054.37 nM, MKPP = 987.96 nM; (B) Predicted steady-state concentration of the kinases.
Niloofar Shahidi (10798605), Michael Pan (5351486), Edmund J. Crampin (7455029), Kenneth Tran (840819), David P. Nickerson (6582578)   +4 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source