Results 71 to 80 of about 1,474,638 (301)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
A new mechanism for LKB1 activation
Molecular & Cellular Oncology, 2018 Liver kinase B1 (LKB1, also known as serine/threonine kinase 11, STK11) has been thought to be a constitutively active tumor suppressor that is activated by forming an active complex.
Szu-Wei Lee, Hui-Kuan Lin
doaj +1 more source
Differentially expressed genes in visceral or subcutaneous adipose tissue of obese men and women
Journal of Lipid Research, 2004 There is growing evidence that the distribution of adipose tissue in the body is of importance in the development of metabolic complications of obesity, such as diabetes, hypertension, and hyperlipidemia.
Kristina Linder +4 more
doaj +1 more source
Synchronizing Data Words for Register Automata
, 2019 Register automata (RAs) are finite automata extended with a finite set of registers to store and compare data from an infinite domain. We study the concept of synchronizing data words in RAs: does there exist a data word that sends all states of the RA ...
Quaas, Karin, Shirmohammadi, Mahsa
core +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
All over the place: deciphering HRAS signaling from different subcellular compartments
Molecular & Cellular Oncology, 2019 RAS (rat sarcoma virus oncogene homolog) oncogenes regulate fundamental biological processes through an ever-expanding signaling network. Using interaction proteomics, phosphoproteomics, transcriptomics, and integration of these datasets with a novel ...
Walter Kolch, David Matallanas
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Revista Colombiana de Ciencias Pecuarias, 2020 Background: Shrimp farming is evolving from semi-intensive to hyper-intensive systems with biofloc technology and water recirculation systems. Objective: To evaluate the transcriptional response promoted by biofloc on shrimp (Litopenaeus vannamei) under ...
Jorge Soto Alcalá +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source