Results 91 to 100 of about 499,302 (317)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Impact of Streptomyces and Bacillus on Ammonia, Nitrite, Vibrio Counts and Growth of Penaeus vannamei in Recirculating Aquaculture System

Journal of Pure and Applied Microbiology
This study evaluates the effects of supplementing whiteleg shrimp (Penaeus vannamei) feed with Streptomyces strains (TM1, TM2, TM7, TM21, TM22), Bacillus strains (AQ1, BIO2, BAL3), and their combinations at different densities (106, 107, and 108 CFU/g ...
To Dinh Phuc, Nguyen Thuy Huong, Pham Minh Tuan, Huynh Thai Truc Linh, Nguyen Thi Ngoc Han, Pham Thi Thu Dan, Bui Thi Hong Linh   +6 more
doaj   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

EVALUACIÓN DE CALIDAD DE AGUA RESIDUAL TRATADA PARA RIEGO EN EL VALLE ALTO DE LA CIUDAD DE COCHABAMBA

Investigación & Desarrollo
El presente estudio se enfoca en analizar la calidad fisicoquímica de los efluentes generados por un grupo de Plantas de Tratamiento de Aguas Residuales (PTAR) situadas en el Valle Alto de Cochabamba para determinar su aptitud de reúso agrícola.
Ivette Echeverría, Gabriel Aliaga, Oliver Saavedra   +2 more
doaj   +1 more source

Graphical Signage Decreases Negative Attitudes towards Robots and Robot Anxiety in Human-Robot Co-working [PDF]

, 2018
To achieve full potential of collaborative robots, human operators need confidence in robotic co-worker technologies and their capacities. We compare the impact of dynamic signage with static signage on the human-robot collaboration task performance ...
Cameron, D., Rolph, J., Aitken, J., Eimontaite, I., Mokaram, S., Law, J., Gwilt, I.   +6 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

SOB 2005 RAS.343

, 2011
onderzoeksrappor
Ras, J.
core   +1 more source

Time course behaviour of the terminal kinases in the composed EGFR-Ras-MAPK bond graph model with negative feedback.

, 2022
Time course behaviour of the terminal kinases in the composed EGFR-Ras-MAPK bond graph model with negative feedback.
Niloofar Shahidi (10798605), Michael Pan (5351486), Edmund J. Crampin (7455029), Kenneth Tran (840819), David P. Nickerson (6582578)   +4 more
core   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source