Results 81 to 90 of about 499,302 (317)
Ras signalling in the fission yeast Schizosaccharomyces pombe [PDF]
Ras signalling is vital to many cellular processes. Ras proteins mediate a vast array of cellular signalling networks, and are conserved from humans to unicellular eukaryotes.
Bond, Michael Edward
core
Comparison of K-Ras and N-Ras Mutagenic Hot Spots for UVC Damage
, 2019 It has been well established that mutations in K-Ras and N-Ras proto-oncogenes can convert them into active oncogenes. Current molecular cancer research has been focused on determining the key steps by which cellular genes become oncogenes and not on the
Nair, Sindhu G., Loppnow, Glen R.
core +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Discovery of a ‘Grail-Shaped’ Drug: Ne-ratinib and the Downregulation of Mutant RAS
European Medical Journal Oncology, 2019 It has been stated that developing a drug that can attack mutated RAS proteins is ‘the Holy Grail’ of cancer therapeutics. Through a series of unexpected findings, the authors discovered that the irreversible epidermal growth factor receptor 1/2/4 ...
Paul Dent +2 more
doaj
The specifics of conducting an audit based on the company’s accounting statements
Ученые записки Российской академии предпринимательстваFinancial statements are one of the most important sources of assessing the state of the enterprise, it was created in order to formalize reports and reduce the uncertainty of documenting the facts of the economic activity of the enterprise. By analyzing
M. N. Smagina +2 more
doaj +1 more source
Ras-transformed EpCAM cells are sensitized with paclitaxel and quercetin.
, 2023 A-B. Phase contrast image of MCF10A-Ras-EpCAM-L240A cells cultured until sub-confluent and treated for 36-h with Veh. (DMSO), MEKi (Ci-1040, 20nm), JNKi (SP600125, 1 μM), P38 MAKPi (SB203580, 100 nM), AKti (LY294002, 2 μM), NF-kBi (BAY117082, 10 μM ...
Narendra V. Sankpal (15082659) +6 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Ras and Ras mutations in cancer
Open Life Sciences, 2013 Abstract Ras genes are pre-eminent genes that are frequently linked with cancer biology. The functional loss of ras protein caused by various point mutations within the gene, is established as a prognostic factor for the genesis of a constitutively active Ras-MAPK pathway leading to cancer. Ras signaling circuit follows a complex pathway,
Rajasekharan Satish, Raman Thiagarajan
openaire +2 more sources
, 1992 Specific antibodies against rap1A and rap1B small GTP-binding proteins were generated by immunization of rabbits with peptides derived from the C-terminus of the processed proteins.
Schwaner, I. +5 more
core +1 more source