Results 61 to 70 of about 499,302 (317)
, 2022 Dolgozatomban egy intenzív (RAS) halnevelő rendszer gazdasági elemzését végeztem el egy 50/év piaci méretű (2,5-3kg) Leső harcsa (Silurus glanis) nevelésére alkalmas halnevelő telep létesítésének, nevelési és fenntartási költségeinek vizsgálatán ...
Pallag, Gábor
core
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Frontiers in Cell and Developmental Biology, 2022 RAS oncogenes are chief tumorigenic drivers, and their mutation constitutes a universal predictor of poor outcome and treatment resistance. Despite more than 30 years of intensive research since the identification of the first RAS mutation, most attempts
Rodrigo E. Cáceres-Gutiérrez +6 more
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Inhibition of Ras oncogenic activity by Ras protooncogenes [PDF]
International Journal of Cancer, 2004 AbstractPoint mutations in ras genes have been found in a large number and wide variety of human tumors. These oncogenic Ras mutants are locked in an active GTP‐bound state that leads to a constitutive and deregulated activation of Ras function. The dogma that ras oncogenes are dominant, whereby the mutation of a single allele in a cell will predispose
Roberto, Diaz +8 more
openaire +2 more sources
Ras-RalGEF-Ral-dependent developmental events in C. elegans development and metabolism
, 2020 Ras is the most mutated oncoprotein, with ~30% of tumors driven by activated Ras. Among three Ras effectors of roughly equivalent oncogenicity, Ras-Raf and Ras-PI3K are well studied, but the downstream mechanisms of Ras-RalGEF-Ral signaling remain poorly
Hanna Shin (8728617) +4 more
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Poorly differentiated thyroid cancer: Clinical, pathological, mutational, and outcome analysis
Indian Journal of Pathology and MicrobiologyIntroduction: Poorly differentiated thyroid cancer (PDTC) remains a challenge not only for pathologists and surgeons because of the difficulties associated with the diagnostic process and the compelling need for difficult thyroidectomy, but it is also of
Amit Agarwal +5 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Molecular Cancer, 2005 Background In cancer, cellular transformation is followed by tumour development. Knowledge on the mechanisms of transformation, involving activation of proto-oncogenes and inactivation of tumour-suppressor genes has considerably improved whereas tumour ...
Dagorn Jean +4 more
doaj +1 more source