Results 61 to 70 of about 350,196 (269)

Ras and Ras mutations in cancer

Open Life Sciences, 2013
Abstract Ras genes are pre-eminent genes that are frequently linked with cancer biology. The functional loss of ras protein caused by various point mutations within the gene, is established as a prognostic factor for the genesis of a constitutively active Ras-MAPK pathway leading to cancer. Ras signaling circuit follows a complex pathway,
Rajasekharan Satish, Raman Thiagarajan
openaire   +2 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Impact of Streptomyces and Bacillus on Ammonia, Nitrite, Vibrio Counts and Growth of Penaeus vannamei in Recirculating Aquaculture System

Journal of Pure and Applied Microbiology
This study evaluates the effects of supplementing whiteleg shrimp (Penaeus vannamei) feed with Streptomyces strains (TM1, TM2, TM7, TM21, TM22), Bacillus strains (AQ1, BIO2, BAL3), and their combinations at different densities (106, 107, and 108 CFU/g ...
To Dinh Phuc, Nguyen Thuy Huong, Pham Minh Tuan, Huynh Thai Truc Linh, Nguyen Thi Ngoc Han, Pham Thi Thu Dan, Bui Thi Hong Linh   +6 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

EVALUACIÓN DE CALIDAD DE AGUA RESIDUAL TRATADA PARA RIEGO EN EL VALLE ALTO DE LA CIUDAD DE COCHABAMBA

Investigación & Desarrollo
El presente estudio se enfoca en analizar la calidad fisicoquímica de los efluentes generados por un grupo de Plantas de Tratamiento de Aguas Residuales (PTAR) situadas en el Valle Alto de Cochabamba para determinar su aptitud de reúso agrícola.
Ivette Echeverría, Gabriel Aliaga, Oliver Saavedra   +2 more
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Local RAS [PDF]

, 2010
The concept of a circulating RAS is well established and known to play an endocrine role in the regulation of fluid homeostasis (see Section 4.1, Chapter 4). However, it is more appropriate to view the RAS in the contemporary notion as an “angiotensin-generating system”, which consists of angiotensinogen, angiotensin-generating enzymes, and ...
openaire   +2 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

The use of biofilters with different types of fillers in recirculation aquatic system (RAS)

Fisheries & Aquatic Life
The aim of this study was to evaluate the effectiveness of using highly porous materials as fillers for biofilters in RAS, such as those with a much higher specific surface area than classical polymer floating bioload, and to determine the optimal ...
Sharylo Dmytro, Kovalenko Vasyl, Matvieiev Mykhailo, Kovalenko Bohdan   +3 more
doaj   +1 more source