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A brief history of RAS and the RAS Initiative
2022In this review, I provide a brief history of the discovery of RAS and the GAPs and GEFs that regulate its activity from a personal perspective. Much of this history has been driven by technological breakthroughs that occurred concurrently, such as molecular cloning, cDNA expression to analyze RAS proteins and their structures, and application of PCR to
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37th Annual IEEE/IFIP International Conference on Dependable Systems and Networks (DSN'07), 2007
Different applications require different levels of fault tolerance. Therefore, it is important to create a flexible architecture that allows a customer to choose the appropriate amount of fault tolerance, a concept we call "RAS by the yard. " In this paper we describe a next generation supercomputer and the design flexibility that allows us to offer a ...
Alan Wood, Swami Nathan
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Different applications require different levels of fault tolerance. Therefore, it is important to create a flexible architecture that allows a customer to choose the appropriate amount of fault tolerance, a concept we call "RAS by the yard. " In this paper we describe a next generation supercomputer and the design flexibility that allows us to offer a ...
Alan Wood, Swami Nathan
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Science, 2005
H-Ras, N-Ras, and K-Ras are homologous signaling molecules that are able to regulate distinct signaling pathways because they inhabit different compartments within the cell. In their Perspective, Meder and Simons discuss new work ( Rocks et al .) showing that N-Ras and H-Ras continuously cycle between the plasma membrane and Golgi ...
Meder, D., Simons, K.
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H-Ras, N-Ras, and K-Ras are homologous signaling molecules that are able to regulate distinct signaling pathways because they inhabit different compartments within the cell. In their Perspective, Meder and Simons discuss new work ( Rocks et al .) showing that N-Ras and H-Ras continuously cycle between the plasma membrane and Golgi ...
Meder, D., Simons, K.
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RAS at 40: Update from the RAS Initiative
Cancer Discovery, 2022Summary: The RAS Initiative was launched in 2013 to address unmet clinical needs of patients with KRAS-driven cancers. The Initiative is based at Frederick National Laboratory for Cancer Research in Frederick, MD, and involves multiple collaborations with the RAS research community in academia and industry with ...
Dwight V. Nissley, Frank McCormick
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Computing, 1979
Given a nonnegative real (m, n) matrixA and positive vectorsu, v, then the biproportional constrained matrix problem is to find a nonnegative (m, n) matrixB such thatB=diag (x) A diag (y) holds for some vectorsx ∈ ℝm andy ∈ ℝn and the row (column) sums ofB equalui (vj)i=1,...,m(j=1,..., n).
Achim Bachem, Bernhard Korte
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Given a nonnegative real (m, n) matrixA and positive vectorsu, v, then the biproportional constrained matrix problem is to find a nonnegative (m, n) matrixB such thatB=diag (x) A diag (y) holds for some vectorsx ∈ ℝm andy ∈ ℝn and the row (column) sums ofB equalui (vj)i=1,...,m(j=1,..., n).
Achim Bachem, Bernhard Korte
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2006
Ras proteins (H-, N-, and K-Ras) are critical components of signal transduction pathways leading from cell-surface receptors to the control of cell proliferation, differentiation or death. Normal Ras proteins exist in equilibrium between an active (Ras-GTP) and an inactive (Ras-GDP) state.
Jose M. Rojas, Eugenio Santos
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Ras proteins (H-, N-, and K-Ras) are critical components of signal transduction pathways leading from cell-surface receptors to the control of cell proliferation, differentiation or death. Normal Ras proteins exist in equilibrium between an active (Ras-GTP) and an inactive (Ras-GDP) state.
Jose M. Rojas, Eugenio Santos
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Current Opinion in Cell Biology, 1996
The search for proteins which interact with the active GTP-bound form of Ras in order to transmit signals for proliferation, differentiation and oncogenesis has been a long one. Now there are several strong candidates for Ras effectors that include protein kinases, lipid kinases and guanine nucleotide exchange factors. Structural information on how one
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The search for proteins which interact with the active GTP-bound form of Ras in order to transmit signals for proliferation, differentiation and oncogenesis has been a long one. Now there are several strong candidates for Ras effectors that include protein kinases, lipid kinases and guanine nucleotide exchange factors. Structural information on how one
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Journal of Cell Science, 1988
ABSTRACT Oncogenic forms of the p21ras genes have been found in a large variety of human malignancies and tumours induced in animals by chemical carcinogens or irradiation. The active form of the p21 ras proteins is the GTP bound state and oncogenic mutations result in the protein being constitutively in the GTP bound active state. There
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ABSTRACT Oncogenic forms of the p21ras genes have been found in a large variety of human malignancies and tumours induced in animals by chemical carcinogens or irradiation. The active form of the p21 ras proteins is the GTP bound state and oncogenic mutations result in the protein being constitutively in the GTP bound active state. There
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Oncology Reports, 1996
A number of proteins and low-molecular weight compounds have been reported to suppress the activity toward ras-oncogenes and their products. These include anti-lias antibody, inhibitors of Ras activation, Ras dominant negative mutants, inhibitors of processing of newly-synthesized Ras, suppressors and inhibitors of downstream effecters and genetic ...
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A number of proteins and low-molecular weight compounds have been reported to suppress the activity toward ras-oncogenes and their products. These include anti-lias antibody, inhibitors of Ras activation, Ras dominant negative mutants, inhibitors of processing of newly-synthesized Ras, suppressors and inhibitors of downstream effecters and genetic ...
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IEEE Robotics & Automation Magazine, 2007
The paper talks about the history of IEEE Robotics and Automation Society (RAS). The RAC (Robotics and Automation Council) was established to provide focus for IEEE activities in R&A field. In the years since RAS was established as a full fledged IEEE Society, it has continued to be one of the most active and innovative societies in the ...
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The paper talks about the history of IEEE Robotics and Automation Society (RAS). The RAC (Robotics and Automation Council) was established to provide focus for IEEE activities in R&A field. In the years since RAS was established as a full fledged IEEE Society, it has continued to be one of the most active and innovative societies in the ...
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