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Rethinking Ras: p21 Ras Proteins and Cardiac Signal Transduction
1995Hypertrophy of cardiac muscle occurs both as the normal mode of ventricular growth after birth and, as a pathophysiological response, in adaptation to mechanical overload [1–3]. Classically, cardiac myocytes lose their proliferative capacity shortly after birth, and subsequent enlargement is due to an increase in cell size, mediated in turn by an ...
Maha Abdellatif, Michael D. Schneider
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Three-dimensional structure of Ras and Ras-related proteins
1995Abstract The structures of several different wild-type and mutantp21 complexes have been determined by two groups. A listof the published structures is shown in Table 1 togetherwith the resolutions obtained in the crystallographic analyses.For wild-type and one oncogenic mutant both thetriphosphate and diphosphate structures have been ...
Alfred Wittinghofer, Alfonso Valencia
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Ras proteins and theras-related signal transduction pathway
Radiation and Environmental Biophysics, 1991Mammalian ras genes may naturally acquire oncogenic transformation potential through some point mutations which result in the impairment of the normal ras protein functions, and which are localised in codons 12, 13 or 61. Mutationally activated ras alleles were found in a wide variety of human and carcinogen (including radiation)-induced animal ...
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[RAS proteins and related proteins].
Comptes rendus des seances de la Societe de biologie et de ses filiales, 1995Since the mid-eighties, numerous small G-proteins of the ras gene superfamily have been identified and characterized; more than sixty members are distributed into four subfamilies: ras, rho, rab and ran. Although it appears that, structurally, the products of the ras superfamily are related and implicated in various and diverse intracellular mechanisms:
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