Results 91 to 100 of about 3,384 (210)

Tumor Lysis Syndrome in Acute Myeloid Leukemia Patients Treated With a Venetoclax Based Regimen

European Journal of Haematology, Volume 114, Issue 4, Page 626-635, April 2025.
ABSTRACT Venetoclax with hypomethylating agents (HMA) is the standard of care for acute myeloid leukemia (AML) in patients ineligible for intensive chemotherapy and is associated with tumor lysis syndrome (TLS). TLS prophylaxis and the use of Cairo Bishop versus Howard diagnostic criteria are not standardized.
Margaret Rowe, Daria Babushok, Martin Carroll, Alison Carulli, Noelle Frey, Saar Gill, Elizabeth Hexner, Rebecca Hirsh, Nasheed Hossain, Catherine Lai, Alison Loren, Selina Luger, Ivan Maillard, Shannon McCurdy, Andrew Matthews, Mary Ellen Martin, Vikram R Paralkar, Alexander Perl, David Porter, Keith Pratz, Edward Stadtmauer, Ximena Jordan Bruno   +21 more
wiley   +1 more source

Real‐World Utilization of Medications With Pharmacogenetic Recommendations in Older Adults: A Scoping Review

Clinical and Translational Science, Volume 18, Issue 2, February 2025.
ABSTRACT Pharmacogenetic testing provides patient genotype information which could influence medication selection and dosing for optimal patient care. Insurance coverage for pharmacogenetic testing varies widely. A better understanding of the commonly used medications with clinically important pharmacogenetic recommendations can inform which ...
Bella D. Ianni, Chin Hang Yiu, Edwin C. K. Tan, Christine Y. Lu   +3 more
wiley   +1 more source

Multi-site investigation of strategies for the clinical implementation of CYP2D6 genotyping to guide drug prescribing [PDF]

, 2019
PURPOSE: A number of institutions have clinically implemented CYP2D6 genotyping to guide drug prescribing. We compared implementation strategies of early adopters of CYP2D6 testing, barriers faced by both early adopters and institutions in the process
Beitelshees, Amber L., Bell, Gillian C., Bishop, Jeffrey R., Blake, Kathryn, Cavallari, Larisa H., Crona, Daniel J., Dressler, Lynn, Duong, Benjamin Q., Empey, Philip E., Gregg, Ryan A., Hicks, J. Kevin, Hines, Lindsay J., Johnson, Julie A., Lee, James C., Limdi, Nita A., Obeng, Aniwaa Owusu, Peterson, Josh F., Pratt, Victoria M., Prows, Cynthia A., Ramsey, Laura B., Scott, Stuart A., Shelton, Richard C., Skaar, Todd C., Smith, D. Max, Tuteja, Sony, Van Driest, Sara L., Weitzel, Kristin Wiisanen   +26 more
core   +1 more source

Value of Pharmacogenetic Testing Assessed with Real‐World Drug Utilization and Genotype Data

Clinical Pharmacology &Therapeutics, Volume 117, Issue 1, Page 278-288, January 2025.
Implementation of pharmacogenetic testing in clinical care has been slow and with few exceptions is hindered by the lack of real‐world evidence on how to best target testing. In this retrospective register‐based study, we analyzed a nationwide cohort of 1,425,000 patients discharged from internal medicine or surgical wards and a cohort of 2,178 ...
Kaisa Litonius, Noora Kulla, Petra Falkenbach, Kati Kristiansson, E. Katriina Tarkiainen, Liisa Ukkola‐Vuoti, Kristiina Cajanus, Mari Korhonen, Sofia Khan, Johanna Sistonen, Arto Orpana, Mats Lindstedt, Tommi Nyrönen, Markus Perola, Miia Turpeinen, Ville Kytö, Aleksi Tornio, Mikko Niemi   +17 more
wiley   +1 more source

Clinical spectrum and severity of hemolytic anemia in glucose 6-phosphate dehydrogenase-deficient children receiving dapsone [PDF]

, 2012
Drug-induced acute hemolytic anemia led to the discovery of G6PD deficiency. However, most clinical data are from isolated case reports. In 2 clinical trials of antimalarial preparations containing dapsone (4,4′-diaminodiphenylsulfone; 2.5 mg/kg once ...
Carter, Nick, Duparc, Stephan, Luzzatto, Lucio, Pamba, Allan, Premji, Zul, Richardson, Naomi D., Tiono, Alfred B.   +6 more
core   +2 more sources

Downregulation of type I interferon signalling pathway by urate in primary human PBMCs

Immunology, Volume 174, Issue 1, Page 100-112, January 2025.
Increased urate concentrations suppress type 1 interferon (IFN1) related signalling pathways in human peripheral blood mononuclear cells (PBMCs) and monocytes in vitro, indicated by transcriptome analysis and reduced STAT1 phosphorylation. Additionally, serum urate concentrations in gout patients show an inverse relationship with interferon‐stimulated ...
Medeea Badii, Valentin Nica, Ancuța R. Straton, Brenda Kischkel, Orsolya Gaal, Georgiana Cabău, Viola Klück, Ioana Hotea, HINT Consortium, Leo A. B. Joosten, Ioan V. Pop, Radu A. Popp, Simona Rednic, Cristina Pamfil, Tania O. Crişan, Marius Farcaş†, Dragoş H. Marginean, Orsolya I. Gaal, Medeea O. Badii, Ioana Hotea, Loredana Peca, Andreea‐Manuela Mirea, Georgiana Cabău, Valentin Nica, Doina Colcear, Mariana S. Pop, Ancuta Rus, Boris Novakovic, Cristina Pamfil, Simona Rednic, Mihai G. Netea, Radu A. Popp, Leo A. B. Joosten, Tania O. Crișan   +33 more
wiley   +1 more source

Management of Pediatric Tumor Lysis Syndrome [PDF]

, 2011
Introduction: Tumor lysis syndrome (TLS) is a serious complication of malignancies and can result in renal failure or death. Review: In tumors with a high proliferative rate with a relatively large mass and a high sensitivity to cytotoxic agents, the ...
Elhoudzi, J, Harif, M, Mahmal, L, Nafil, H, Tazi, I   +4 more
core   +2 more sources

Uricases: reflections on recent developments in the management of challenging gout patients [PDF]

Exploration of Musculoskeletal Diseases
Oral urate-lowering therapy (ULT) is key to treating gout. However, many patients receiving oral ULT do not achieve the target serum urate (SU) levels, partly because some patients cannot tolerate or have contraindications to their use, mainly due to ...
Naomi Schlesinger, Dan Kaufmann
doaj   +1 more source

RASBURICASE-INDUCED METHEMOGLOBINEMIA [PDF]

, 2023
Haneen Mallah
openalex   +1 more source

Tumor Lysis Syndrome in a Patient With Gastric Adenocarcinoma

Journal of Investigative Medicine High Impact Case Reports, 2020
Tumor lysis syndrome (TLS) is a severe metabolic complication that usually occurs in patients with aggressive tumors who undergo treatment with chemotherapy. Traditionally, it was mainly associated with hematologic malignancies.
Prasanth Lingamaneni MD, Parth Desai MD, Madhu Mathew Vennikandam MD, Krishna Moturi MD, Anmol Baranwal MD, Shweta Gupta MD   +5 more
doaj   +1 more source