Tophus burden reduction with pegloticase: results from phase 3 randomized trials and open-label extension in patients with chronic gout refractory to conventional therapy [PDF]
, 2013 INTRODUCTION: Two replicate randomized, placebo-controlled six-month trials (RCTs) and an open-label treatment extension (OLE) comprised the pegloticase development program in patients with gout refractory to conventional therapy.
Baraf, Herbert SB +9 more
core +2 more sources
Erythrocyte hemighosts in a patient with tumor lysis syndrome: One train may hide another
Clinical Case Reports, 2020 Rasburicase was introduced to treat hyperuricemia secondary to tumor lysis syndrome. Because of severe hemolytic anemia, a blood smear was requested and showed hemighosts, revealing G6PD deficiency.
Pierre Cabantous +2 more
doaj +1 more source
Congenital acute myeloid leukemia with unique translocation t(11;19)(q23;p13.3) [PDF]
, 2015 Congenital leukemia is rarely encountered in clinical practice, even in tertiary children's hospitals. Leukemia may cause significant coagulopathy, putting the patient at risk of intracranial hemorrhage.
Bandt, S. Kathleen +8 more
core +3 more sources
Study protocol for THINK : a multinational open-label phase I study to assess the safety and clinical activity of multiple administrations of NKR-2 in patients with different metastatic tumour types [PDF]
, 2017 Introduction: NKR-2 are autologous T cells genetically modified to express a chimeric antigen receptor (CAR) comprising a fusion of the natural killer group 2D (NKG2D) receptor with the CD3 zeta signalling domain, which associates with the adaptor ...
Aftimos, Philippe +15 more
core +1 more source
ANURIA SECONDARY TO HOT WEATHER-INDUCED HYPERURICAEMIA: DIAGNOSIS AND MANAGEMENT [PDF]
, 2003 There is little information on the management of anuria secondary to severe volume depletion or as a rare manifestation of heat stroke in areas of the world with very hot summers.
Abdul-Halim, Hamdy +6 more
core +1 more source
Burkitts's lymphoma - an atypical presentation. [PDF]
, 2000 BACKGROUND: In female adolescents and young adults, malignancies of the genital tract are the most frequent type of cancer, closely followed by Hodgkin's and non-Hodgkin's lymphomas.
Beck-Popovic, M. +3 more
core +3 more sources
Why do papers have many Mendeley readers but few Scopus-indexed citations and vice versa? [PDF]
, 2015 Counts of citations to academic articles are widely used as indicators of their scholarly impact. In addition, alternative indicators derived from social websites have been proposed to cover some of the shortcomings of citation counts. The most promising
Haustein S, Mike Thelwall
core +2 more sources
International Journal of Laboratory Hematology, EarlyView.ABSTRACT Background G6PD deficiency affects about 500 million people worldwide and is prevalent in many malaria‐endemic settings. People with G6PD deficiency are at risk of hemolysis when exposed to certain medications, including 8‐aminoquinoline drugs used to treat Plasmodium vivax malaria.
Flavia Regina Medeiros da Silva +7 more
wiley +1 more source
Pediatric Emergency Medicine Journal, 2016 Tumor lysis syndrome (TLS) is an oncologic emergency due to the rapid lysis of tumor cells and subsequent release of large amounts of intracellular potassium, phosphate, and uric acid into the bloodstream.
Hyery Kim
doaj +1 more source
European Journal of Haematology, Volume 116, Issue 2, Page 160-168, February 2026.ABSTRACT Acute myeloid leukemia (AML) in elderly patients presents a major therapeutic challenge, as many are deemed unfit for intensive chemotherapy due to age, comorbidities, or frailty. Venetoclax in combination with hypomethylating agents (HMA) has emerged as a standard‐of‐care for this population, yet outcomes remain heterogeneous and predictive ...
Ernesto Vigna +11 more
wiley +1 more source