Results 171 to 180 of about 1,228 (214)
. ABSTRACT Redox‐targeting flow batteries (RTFBs) present an attractive strategy for enhancing the energy density of conventional redox flow batteries (RFBs) by integrating heterogeneous energy storage materials as capacity boosters. However, nearly all RTFB systems have been developed with nonaqueous redox chemistries, while capacity boosters in ...
Yuxin Liu +4 more
wiley +1 more source
ABSTRACT CDK4/6 inhibitors combined with endocrine therapy are the standard first‐line treatment for hormone receptor‐positive (HR+) HER2‐negative metastatic breast cancer. However, a substantial proportion of patients experience early disease progression in routine practice. Clinicians currently lack practical tools at treatment initiation to identify
Mobina Shrestha +3 more
wiley +1 more source
Demonstrating pharmacological effects in early‐phase oncology clinical trials remains challenging, largely due to the lack of robust pharmacodynamic markers. Lipopolysaccharide (LPS) is used as an immune challenge agent in healthy participants to study drugs for autoimmune conditions.
Igor Radanović +11 more
wiley +1 more source
Orforglipron is an orally administered, small‐molecule glucagon‐like peptide‐1 receptor agonist in clinical development for the treatment of type 2 diabetes and obesity. Orforglipron is a substrate of CYP3A4, organic anion transporting polypeptides (OATPs) 1B/1B3, and P‐glycoprotein (P‐gp); however, precipitants commonly used to define these mechanisms
Bridget L. Morse +7 more
wiley +1 more source
An ultrasensitive LC‐MS/MS method for detecting testosterone esters (T‐esters) in urine at sub–pg/mL levels is presented. This approach, employing Girard P derivatization, provides the first evidence of T‐esters' trace‐level detectability in human urine.
Daniel Pecher +3 more
wiley +1 more source
The role of Rho GTPases in facial morphogenesis
The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley +1 more source
Abstract Background Endocytosis constitutes a fundamental cellular process governing development through coordinated regulation of plasma membrane remodeling and ciliogenesis, processes essential for cell shape changes and tissue development. Although Twist1 null embryos display complete cranial neural tube (NT) closure defects and conditional knockout
Derrick Thomas +8 more
wiley +1 more source

