Results 71 to 80 of about 181 (177)

Forebyggende arbeid mot rasisme

, 2023
Denne masteroppgaven har til hensikt med å finne ut hvordan skoleledelsen ved bergensskoler beskriver arbeidet sitt mot og med rasisme og diskriminering. I oppgaven legges det til grunn at skolen er en viktig arena rundt forebygging av rasisme, diskriminering, fordommer og andre antidiskriminerende holdninger.
openaire   +1 more source

AI‐Assisted Digital Single‐Molecule Activity Tracker for Decoupling Intrinsic Heterogeneity from Photo‐Oxidative Damage in High‐Photon‐Flux Enzymology

Advanced Science, EarlyView.
Employing a digital single‐molecule activity tracker (dSMAT), this research demonstrates that high‐photon‐flux irradiation drives progressive oxidative scarring in polymerases. Unlike simple thermal denaturation, real‐time kinetic tracking dynamically visualizes enzymes degrading into multiple impaired subpopulations.
Anran Zheng, Qi Yang, Jinze Li, Fuqiang Ma, Xuefeng Wang, Zhen Guo, Chuanyu Li, Dongshu Li, Jia Yao, Zhiqi Zhang, Wei Zhang, Lianqun Zhou   +11 more
wiley   +1 more source

DHODH Drives Sunitinib Resistance Via a Non‐Enzymatic Mechanism by Inhibiting TRIM28 Ubiquitination and Consequent VEGFA Activation in RCC

Advanced Science, EarlyView.
This non‑enzymatic function of DHODH drives sunitinib resistance by competing with TRIM37 to block TRIM28 ubiquitination, thereby stabilizing TRIM28 and activating VEGFA transcription. Disrupting the DHODH–TRIM28 interaction with lisaftoclax restores drug sensitivity.
Shijie Qian, Shihang Pu, Zhipeng Xu, Yiheng Ding, Ling Jin, Baochao Li, Qi Li, Xiaohai Xi, Zengjun Wang, Jiajun Xing, Aiming Xu   +10 more
wiley   +1 more source

Nanozyme‐Reinforced miR‐197‐3p Delivery Resets Metabolic and Senescence Pathways to Rejuvenate Osteoarthritic Cartilage

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a progressive and disabling joint disease driven by oxidative stress, chondrocyte senescence and extracellular matrix (ECM) degradation, yet lacks effective disease‐modifying treatments. In this study, we identified miR‐197‐3p as a previously unrecognized, cartilage‐protective miRNA significantly downregulated in both ...
Xuejie Cai, Zehui Lv, Chen Zhang, Xingdong Yang, Ruoying Wang, Yixin Bian, Jiawei Xu, Han Wang, Yingjie Wang, Long Bai, Jiacan Su, Xisheng Weng   +11 more
wiley   +1 more source

Rasisme i plural form. Paradigmer og begreper om rasisme

, 1997
"Rasisme" er et ord som hyppig benyttes uten at dets innhold defineres nærmere. Den offentlige debatt gir oss inntrykk av at ordet har et entydig innhold. Det er et stort sprik fra denne tilsynelatende konsensus til de til dels krasse strider som har blitt ført om rasismebegrepet innenfor samfunnsvitenskap og humaniora.
openaire   +1 more source

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

Advanced Science, EarlyView.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li, Simin Chen, Huijuan Hu, Shiyao Wu, Jingnan Wang, Kai Sun, Chenxi Peng, Suling Liu, Shuoyang Zhang, Yu Kuang, Wei Chen, Qian Qiu, Liuqin Liang, Yu Wen, Hanshi Xu, Youjun Xiao   +15 more
wiley   +1 more source

Kaempferol Attenuates Spaceflight‐Associated Knee Cartilage Degradation by Targeting NOX4‐Mediated Mitochondrial Dysfunction

Advanced Science, EarlyView.
We have shown that both simulated and actual spaceflight contribute to cartilage degradation in the knees of mice. Using RNA sequencing and bioenergetic profiling, we identified NADPH oxidase 4 (NOX4) as a key factor driving these changes. Additionally, we found that kaempferol, a naturally occurring flavonoid that binds directly to NOX4, reduces ...
Yuesong Yin, Ruiling Xu, Meagan J. Makarczyk, Jia‐Jun Liu, Silvia Liu, Matthew Z. Shi, Roberta Di Carlo, Michael F. Almeida, Alex Garris, Sarah Day, Rebekah Sanchez‐Hodge, Jonathan C. Schisler, Aleeza H. Zilberman, Noah G. Allen, Angela J. Kubik, Elizabeth A. Blaber, Arnold Z. Olali, Wanqing Xie, Douglas C. Wallace, Christopher E. Mason, Peter G. Alexander, Giuseppe Intini, Afshin Beheshti, Hang Lin   +23 more
wiley   +1 more source

RETRACTION: Differential Involvement of Ras‐GRF1 and Ras‐GRF2 in L‐DOPA‐Induced Dyskinesia

Annals of Clinical and Translational Neurology, EarlyView.
RETRACTION: S. Bido, N. Solari, M. Indrigo, A. D’Antoni, R. Brambilla, M. Morari, and S. Fasano, “Differential Involvement of Ras‐GRF1 and Ras‐GRF2 in L‐DOPA‐Induced Dyskinesia,” Annals of Clinical and Translational Neurology 2, no. 6 (2015): 662–678, https://doi.org/10.1002/acn3.202. The above article, published online on 24 April 2015 in Wiley Online
wiley   +1 more source

Enhanced Ionic Conductivity at the Solid Electrolyte Interphase of Oxygen‐Doped Li6PS5Cl

Advanced Science, EarlyView.
Machine‐learned molecular dynamics and machine‐learning‐based phase identification reveal the kinetically formed SEI at buried Li | Li6PS5Cl interfaces. The SEI is dominated by Li2S‐based anion‐substituted phases, while oxygen doping enhances SEI ionic conductivity.
Sojeong Yang, Sungwoo Kang, Atefeh Yadegarifard, Hyun‐Jae Lee, Nongnuch Artrith, Jung‐Hoon Lee, Byungju Lee   +6 more
wiley   +1 more source

Undoing the unspeakable: researching racism in Swedish healthcare using a participatory process to build dialogue. [PDF]

Health Res Policy Syst, 2019
Bradby H, Thapar-Björkert S, Hamed S, Ahlberg BM.   +3 more
europepmc   +1 more source