Results 61 to 70 of about 2,841,411 (301)

Cytoskeletal turnover and Myosin contractility drive cell autonomous oscillations in a model of Drosophila Dorsal Closure [PDF]

, 2014
Oscillatory behaviour in force-generating systems is a pervasive phenomenon in cell biology. In this work, we investigate how oscillations in the actomyosin cytoskeleton drive cell shape changes during the process of Dorsal Closure, a morphogenetic event
Blanchard, Guy B., Duque, Julia, Gorfinkiel, Nicole, Machado, Pedro F.   +3 more
core   +3 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

The effects of high-intensity warm-up sets on bench press strength

Motriz: Revista de Educacao Fisica, 2020
Aims: Movement specific warm-up is a widely accepted practice in the sports environment; however, little is known regarding the ideal intensity of its performance.
Mateus de L. Rodrigues, Franciel J. Arantes, João Elias D. Nunes, Frederico B. Lizardo, Guilherme G. de Agostini, Igor M. Mariano, Cristiano L. M. de Barros   +6 more
doaj   +1 more source

Explosive reconnection in magnetars

, 2003
X-ray activity of Anomalous X-ray Pulsars and Soft Gamma-Ray Repeaters may result from the heating of their magnetic corona by direct currents dissipated by magnetic reconnection.
Aschwanden, Aschwanden, Blackman, Browning, Chandrasekhar, Cline, Coroniti, Cutler, de Groot, Duncan, Furth, Galeev, Galeev, Gavriil, Gedalin, Göğüş, Göğüş, Heyl, Kadomtsev, Kennel, Komissarov, Kouveliotou, Low, Lu, Lyubarsky, Lyutikov, Maxim Lyutikov, Mazets, Mereghetti, Palmer, Priest, Sakai, Shivamoggi, Terrel, Thompson, Thompson, Thompson, Thompson, Thompson, Thompson, Uchida, White, Woods, Woods, Woods, Zelenyi   +45 more
core   +2 more sources

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Kinetic Analysis of Lower Body Resistance Training Exercises [PDF]

, 2010
This study evaluated and compared the peak vertical ground reaction force (GRF) and rate of force development (RFD) for the eccentric and concentric phases of 4 lower body resistance training exercises, including the back squat, deadlift, step-up, and ...
Ebben, William, Fauth, McKenzie L., Garceau, Luke, Gray, Aaron, Lutsch, Brittney, Szalkowski, Chris, Wurm, Brad   +6 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

On the rate-limiting dynamics of force development in muscle

Journal of Experimental Biology
ABSTRACT Skeletal muscles produce forces relatively slowly compared with the action potentials that excite them. The dynamics of force production are governed by multiple processes, such as calcium activation, cycling of cross-bridges between myofilaments, and contraction against elastic tissues and the body. These processes have been
Tim J. van der Zee, Jeremy D. Wong, Arthur D. Kuo   +2 more
openaire   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Isometric muscle force, rate of force development and knee extensor neuromuscular efficiency asymmetries at different age groups

Revista Brasileira de Cineantropometria e Desempenho Humano, 2014
The aim of this study was to evaluate force, rate of force development and knee extensor neuromuscular efficiency asymmetries in children, adults and elderly.
Helen L Schimidt, Álvaro S Machado, Marco A Vaz, Felipe P Carpes   +3 more
doaj   +1 more source