Results 81 to 90 of about 2,841,411 (301)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Impact of Stiffness of Quadriceps on the Pedaling Rate of Maximal Cycling

Life
Propulsive power is one of the factors that determine the performance of sprint cycling. Pedaling rate is related to power output, and stiffness is associated with improving performance in athletic tasks.
Loi Ieong, Xindi Ni, Huisong Xie, Ye Liu
doaj   +1 more source

An Intramuscular Injection of Mixed Testosterone Esters Does Not Acutely Enhance Strength and Power in Recreationally Active Young Men

Frontiers in Physiology, 2020
Purpose: Limited data are available on the acute performance-enhancing effects of single-dose administration of testosterone in healthy humans. Studies of testosterone administrations to healthy humans are rare due to the difficult nature and necessity ...
Sara Amalie Solheim, Sara Amalie Solheim, Jakob Mørkeberg, Anders Juul, Stine Yde Freiesleben, Emmie N. Upners, Yvette Dehnes, Nikolai Baastrup Nordsborg   +7 more
doaj   +1 more source

An empirical analysis of the effect of labour market characteristics on marital dissolution rates [PDF]

The development in the 1960s of the divorce rate is strikingly similar for the USA and Denmark where the rate in both cases increases very fast from 1967-68 until the mid 1970s.
Bentzen, Jan, Smith, Valdemar
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

The Effect of Physical Exercise Training on Neck and Shoulder Muscle Function Among Military Helicopter Pilots and Crew: A Secondary Analysis of a Randomized Controlled Trial

Frontiers in Public Health, 2020
Introduction: This study presents secondary outcome analyses, in terms of muscle function [i.e., maximal voluntary contraction (MVC) and rate of torque development (RTD)] from a parallel group, single blinded, randomized controlled trial introducing a ...
Mike Murray, Britt Lange, Karen Søgaard, Karen Søgaard, Gisela Sjøgaard   +4 more
doaj   +1 more source

Jeans type analysis of chemotactic collapse

, 2008
We perform a linear dynamical stability analysis of a general hydrodynamic model of chemotactic aggregation [Chavanis & Sire, Physica A, in press (2007)].
Alastuey, Biler, Biler, Biler, Binney, Brenner, Carmeliet, Chaplain, Chavanis, Chavanis, Chavanis, Chavanis, Chavanis, Chavanis, Chavanis, Chavanis, Chavanis, Chavanis, Childress, Clément Sire, Dolbeault, Filbet, Gamba, Herrero, Herrero, Herrero, Hillen, Horstmann, Jäger, Keller, Murray, Nagai, Nanjundiah, Othmer, Pais, Peebles, Pierre-Henri Chavanis, Sire, Sire, Sire, Tsallis, Vergassola   +41 more
core   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The Role of Lower Limb Kinetics in Boxing Punches and the Impact of Fatigue on Biomechanical Performance

Bioengineering
Purpose: This study investigated the contribution of lower limb kinetics to punch performance in amateur boxing and examined the effects of fatigue on biomechanical efficiency.
Charles Stewart, Ross Cornett, Julien S. Baker, Yaodong Gu, Frédéric Dutheil, Ukadike Chris Ugbolue   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source