Results 91 to 100 of about 912,950 (301)

Structural Design and Test of ROP Improving Tool with Adjustable Impact Frequency

Shiyou jixie
Rocks below the Permian are less drillable, leading to low rate of penetration(ROP), which can hardly be improved by only applying the drilling tool with single impact frequency.In this study, a ROP improving tool with adjustable impact frequency was ...
Tian Yu, Zhang Xin, Zhang Pengxiang, Sun Yaoning, Xu Chenxing, Song Xiyan   +5 more
doaj  

Thermally Assisted Penetration and Exclusion of Single Vortex in Mesoscopic Superconductors

, 2012
A single vortex overcoming the surface barrier in a mesoscopic superconductor with lateral dimensions of several coherence lengths and thickness of several nanometers provides an ideal platform to study thermal activation of a single vortex.
B. Petukhov, Lev N. Bulaevskii, M. Tinkham, Matthias J. Graf, Shi-Zeng Lin, Takahiro Nishio, Yukio Hasegawa   +6 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Evolution of penetration mechanism induced by strain rate effect

EPJ Web of Conferences, 2018
According to the dynamic mechanical properties, in the striking velocity range, the strain rate of the projectile and target caused by penetration can reach 104~106 /s. The strain rate effect increases sharply and then tends to saturation.
Li Gan, Song Chunming, Wang Mingyang
doaj   +1 more source

Consumer Learning and Hybrid Vehicle Adoption [PDF]

We study the diffusion of hybrid vehicles among consumers. Using data on sales of 11 different models over seven years, we identify the effect of the penetration rate--total cumulative hybrid sales per capita--on new hybrid purchases.
Heutel, Garth, Muehlegger, Erich
core   +1 more source

Concurrent Optimization of Vehicle Dynamics and Powertrain Operation Using Connectivity and Automation

, 2020
Connected and automated vehicles (CAVs) provide the most intriguing opportunity to reduce energy consumption and travel delays. In this paper, we propose a two-level control architecture for CAVs to optimize (1) the vehicle's speed profile, aimed at ...
Mahbub, A M Ishtiaque, Malikopoulos, Andreas A.   +1 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Prediction for Rate of Penetration Based on PCA-BP Algorithm

Shiyou jixie, 2023
Rate of penetration(ROP)is an important index to measure drilling efficiency.Accurate prediction of ROP plays an important role in improving drilling efficiency and reducing costs,but the commonly used ROP equation prediction model has difficulties in ...
Tang Ming, Wang Hanchang, He Shiming, Zhang Guangfu, Kong Linghao   +4 more
doaj  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Optimal bit selection for large-diameter wellbore drilling in an ultra-deep well

Petroleum Exploration and Development
To optimize the bit selection for large-diameter wellbore in the upper section of an ultra-deep well S-1, a full-well dynamic model integrating drill string vibration and bit rock-breaking was established and then verified using measured vibration data ...
Lili CHEN, Wenzhe LI, Jianhua GUO, Ke LI, Zhixiang CAI, Jie WU, Weining XU, Xiaohua ZHU   +7 more
doaj   +1 more source