Results 201 to 210 of about 60,078 (296)

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Assessing Overall Survival Benefits in Advanced Cancers: The Role of External Comparator Cohort Studies with Real-World Data. [PDF]

Clin Pharmacol Ther
Pignatti F, El-Galaly TC, Kaiser M, Porkka K, Doeswijk R, Mol P, Rivera DR, Lerro CC, Rohr UP, Verpillat P, Valachis A, Trapani D, Di Maio M, Latino N, Cordoba R, Cherny N, Koopman M, Martins-Branco D, Pentheroudakis G, Postmus D.   +19 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Florzolotau (18F) retention is linked to neuropsychological performance in tauopathy. [PDF]

Alzheimers Dement
Shimizu A, Iwabuchi Y, Bun S, Watanabe M, Kubota M, Shimohama S, Tezuka T, Takahata K, Tabuchi H, Seki M, Momota Y, Yamamoto Y, Shikimoto R, Mimura Y, Kurose S, Sakurai R, Takayama T, Hoshino Y, Hoshino T, Suzuki N, Morimoto A, Osumi A, Mimura M, Jinzaki M, Ito D.   +24 more
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Do Stronger Employer Responsibilities Enhance Work Accommodation for Sick-Listed Workers? Evidence From a Dutch Reform. [PDF]

Health Econ
Jansen L, Angelini V, Groneck M, van Ooijen R.   +3 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Air Quality Risks in Public Housing.

JAMA Health Forum
Sheehan BE, Caraballo Velez C, Rees VW, O'Neal MT, Moore KE, Jones KM, Meadows J, Gehlert S, Grucza R, Plunk A, England KJ.   +10 more
europepmc   +1 more source

Near-field and far-field exposures to radiofrequency electromagnetic fields and cancer risks in humans: a protocol for an umbrella review of epidemiological studies. [PDF]

Syst Rev
Ziegler JL, Lagorio S, Mattsson MO, Zeni O, Bolte J, Ledent M, Velghe M, Stam R, Rijs K, Deltour I, Dolatkhah R, Wollschläger D, Petroulakis N, Ortolano LC, Baaken D.   +14 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source