Results 81 to 90 of about 489,800 (291)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
INTERNATIONAL RATING AGENCIES APPROACHES TO THE EVALUATION OF INSURANCE COMPANIES
Фінансово-кредитна діяльність: проблеми теорії та практики, 2017 Growing need for an independent evaluation of the performance results of insurance companies is due to the need to meet the needs of stakeholders to reliable information about the evaluation results of insurers.
S. A. Achkasova +2 more
doaj +1 more source
EU sovereign ratings lags prior and after the great recession [PDF]
, 2019 Mestrado em Economia Monetária e FinanceiraEstudamos as variáveis que mais afetam a alteração dos ratings soberanos na UE para as agências de classificação de crédito Fitch e S&P.
Paineli, Grazielli Angelucci
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Anales de Psicologia, 2018 By using computer program we created a virtual environment to study the possible impacts of sense of agency and sense of ownership on anxiety. The aim of the present study is to investigate whether our setup could achieve the similar effect as ...
Zhang Jing, Chen Wei, Qian Yanyan
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
The Effect of Rating Agencies on Herd Behaviour [PDF]
This paper purports to provide some evidence on the effect of rating agencies on herding in financial markets. By means of a laboratory experiment, we investigate the effect and interaction between private and public information.
Andrea Morone, Giovanni Ferri
core
European versus Anglo-Saxon credit view: Evidence from the eurozone sovereign debt crisis
, 2016 We analyse whether different levels of country ties to Europe among the rating agencies Moody's, S&P, and Fitch affect the assignment of sovereign credit ratings, using the Eurozone sovereign debt crisis of 2009-2012 as a natural laboratory. We find that
Altdörfer, Marc +3 more
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
A Credit Rating Model in a Fuzzy Inference System Environment
Algorithms, 2019 One of the most important functions of an export credit agency (ECA) is to act as an intermediary between national governments and exporters. These organizations provide financing to reduce the political and commercial risks in international trade.
Amir Karbassi Yazdi +3 more
doaj +1 more source