Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Electrohydrodynamic linear stability analysis of dielectric liquids subjected to unipolar injection in a rectangular enclosure with rigid sidewalls [PDF]
, 2014 We investigate the linear stability threshold of a dielectric liquid subjected to unipolar injection in a 2D rectangular enclosure with rigid boundaries.
Pérez Izquierdo, Alberto Tomás +3 more
core
The Interstellar Rubidium Isotope Ratio toward Rho Ophiuchi A
, 2004 The isotope ratio, 85Rb/87Rb, places constraints on models of the nucleosynthesis of heavy elements, but there is no precise determination of the ratio for material beyond the Solar System.
David C. Knauth +9 more
core +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Financial Ratio Analysis: the Development of a Dedicated Management Information System [PDF]
Theoretical and Applied Economics, 2007 This paper disseminates the results of the development process for a financial analysis information system. The system has been subject to conceptual design using the Unified Modeling Language (UML) and has been implemented in object-oriented manner ...
Voicu-Dan Dragomir
doaj +1 more source
Breast Cancer Patients With Positive Apical or Infraclavicular/Ipsilateral Supraclavicular Lymph Nodes Should Be Excluded in the Application of the Lymph Node Ratio System. [PDF]
Front Cell Dev Biol, 2022 Wang Z +8 more
europepmc +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Harmless delays in a discrete ratio-dependent periodic predator-prey system
Discrete Dynamics in Nature and Society, 2006 Verifiable criteria are established for the existence of positive periodic solutions and permanence of a delayed discrete periodic predator-prey model with Holling-type II functional response N1(k+1)=N1(k)exp{b1(k)−a1(k)N1(k−[τ1])−α1(k)N2(k)/(N1(k)+m(k ...
Yong-Hong Fan, Wan-Tong Li
doaj +1 more source
Lymph Node Ratio System for N Staging of Gastric Cancer: Challenging for Universal Application But Useful for the Prognostic Prediction of Individual Patients. [PDF]
J Gastric Cancer, 2021 Kong SH.
europepmc +1 more source