Results 111 to 120 of about 8,071,777 (301)

D/H ratios of the inner Solar System [PDF]

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2017
The original hydrogen isotope (D/H) ratios of different planetary bodies may indicate where each body formed in the Solar System. However, geological and atmospheric processes can alter these ratios through time. Over the past few decades, D/H ratios in meteorites from Vesta and Mars, as well as from S- and C-type asteroids, have been measured. The aim
openaire   +3 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Harmless delays in a discrete ratio-dependent periodic predator-prey system

Discrete Dynamics in Nature and Society, 2006
Verifiable criteria are established for the existence of positive periodic solutions and permanence of a delayed discrete periodic predator-prey model with Holling-type II functional response N1(k+1)=N1(k)exp⁡{b1(k)−a1(k)N1(k−[τ1])−α1(k)N2(k)/(N1(k)+m(k ...
Yong-Hong Fan, Wan-Tong Li
doaj   +1 more source

Stable Carbon Isotope Ratio (δ13C) Measurement of Graphite Using EA-IRMS System

Medžiagotyra, 2015
δ13C values in non-irradiated natural graphite were measured. The measurements were carried out using an elemental analyzer combined with stable isotope ratio mass spectrometer (EA-IRMS). The samples were prepared with ground and non-ground graphite, the
Andrius Garbaras, Edmundas Bružas, Vidmantas Remeikis   +2 more
doaj   +1 more source

The Interstellar Rubidium Isotope Ratio toward Rho Ophiuchi A

, 2004
The isotope ratio, 85Rb/87Rb, places constraints on models of the nucleosynthesis of heavy elements, but there is no precise determination of the ratio for material beyond the Solar System.
David C. Knauth, David L. Lambert, Edvardsson B., Gratton R. G., Hudson R. D., Lambert D. L., Lemoine M., Marr G. V., Pequignot D., S. R. Federman   +9 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A more stringent constraint on the mass ratio of binary neutron star merger GW170817

, 2017
Recently, the LIGO-Virgo collaboration reported their first detection of gravitational wave (GW) signals from a low mass compact binary merger GW170817, which is most likely due to a double neutron star (NS) merger.
Ai, Shunke, Cao, Zhoujian, Gao, He, Zhang, Bing   +3 more
core   +1 more source

Compressibility of biological systems: the viscoelastic Poisson’s ratio [PDF]

Advances in Physics: X
Soft tissues carry out their vital biological functions within a dynamic mechanical framework that can be extended or compressed. Externally or internally applied uni-axial or biaxial changes induce longitudinal strains that can be of either sign. The complex interrelationship between applied strain and induced strain is quantified by a time-space ...
Pajic-Lijakovic, Ivana, Milivojevic, Milan, McClintock, Peter V E   +2 more
openaire   +3 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source