Results 41 to 50 of about 30,459 (317)

Rational subsets of partially reversible monoids

Theoretical Computer Science, 2008
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A predictive design framework for optimizing CoFe2O4@BaTiO3 magnetoelectric nanoparticles for noninvasive brain stimulation

Materials & Design
Magnetoelectric nanoparticles (MENs) are emerging as promising candidates for wireless and minimally invasive deep brain stimulation, yet rational design strategies to maximize their magnetoelectric (ME) efficiency remain elusive.
Gawtak Kim, Yaser Hadadian, Thanh-Luu Cao, Jungwon Yoon   +3 more
doaj   +1 more source

Staggered fermions simulations on GPUs

, 2010
We present our implementation of the RHMC algorithm for staggered fermions on Graphics Processing Units using the NVIDIA CUDA programming language. While previous studies exclusively deal with the Dirac matrix inversion problem, our code performs the ...
Bonati, Claudio, Cossu, Guido, D'Elia, Massimo, Di Giacomo, Adriano   +3 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Rationally Designed Dynamic Protein Hydrogels with Reversibly Tunable Mechanical Properties [PDF]

Biophysical Journal, 2016
Protein hydrogels have attracted considerable interest due to their potential applications in biomedical engineering. Creating protein hydrogels with dynamic mechanical properties is challenging. Here, the engineering of a novel, rationally designed protein-hydrogel is reported that translates molecular level protein folding-unfolding conformational ...
Kong, Na, Li, Hongbin
openaire   +1 more source

Targeting Cardiac Stem Cell Senescence to Treat Cardiac Aging and Disease

Cells, 2020
Adult stem/progenitor are a small population of cells that reside in tissue-specific niches and possess the potential to differentiate in all cell types of the organ in which they operate.
Eleonora Cianflone, Michele Torella, Flavia Biamonte, Antonella De Angelis, Konrad Urbanek, Francesco S. Costanzo, Marcello Rota, Georgina M. Ellison-Hughes, Daniele Torella   +8 more
doaj   +1 more source

Non-reversibility and self-joinings of higher orders for ergodic flows [PDF]

, 2012
By studying the weak closure of multidimensional off-diagonal self-joinings we provide a criterion for non-isomorphism of a flow with its inverse, hence the non-reversibility of a flow. This is applied to special flows over rigid automorphisms.
Fraczek, K., Kulaga, J., Lemanczyk, M.
core  

High rates of fuel consumption are not required by insulating motifs to suppress retroactivity in biochemical circuits

, 2017
Retroactivity arises when the coupling of a molecular network $\mathcal{U}$ to a downstream network $\mathcal{D}$ results in signal propagation back from $\mathcal{D}$ to $\mathcal{U}$.
Deshpande, Abhishek, Ouldridge, Thomas E.   +1 more
core   +1 more source