Results 101 to 110 of about 159,936 (305)
A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling +16 more
wiley +1 more source
The Bisector Surface of Rational Space Curves
, 2008 Given a point and a rational curve in the plane, their bisector curve is rational [Farouki and Johnstone 1994a]. However, in general, the bisector of two rational curves in the plane is not rational [Farouki and Johnstone 1994b].
MYUNG-SOO KIM, Gershon Elber
core
[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich +19 more
wiley +1 more source
Infinitesimal deformations of rational surface automorphisms
, 2017 International audienceIf $X$ is a rational surface without nonzero holomorphic vector field and $f$ is an automorphism of $X$, we study in several examples the Zariski tangent space of the local deformation space of the pair $(X, f)$
Julien Grivaux, Grivaux, Julien
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon +11 more
wiley +1 more source
Rational cubic trigonometric surface of the positive data.
, 2015 Rational cubic trigonometric surface of the positive data.
Malik Zawwar Hussain (752037) +2 more
core +1 more source
Rational cuspidal curves with four cusps on Hirzebruch surfaces
Le Matematiche, 2014 The purpose of this article is to shed light on the question of how many and what kind of cusps a rational cuspidal curve on a Hirzebruch surface can have.
Torgunn Karoline Moe
doaj
LubricantsSpherical bearings play a crucial role in maintaining the safety of bridge systems. The frequent operation and wear rate over their lifespan highlight the necessity for methods to improve their tribological performance.
Qian Hu, Qingxiang Pei, Pei Li
doaj +1 more source
An isogeometric Reissner–Mindlin shell element based on mixed grid
Advances in Mechanical Engineering, 2018 We propose in this article a new isogeometric Reissner–Mindlin degenerated shell element for linear analysis. It is based on the mixed use of non-uniform rational basis spline and Lagrange basis functions in the same domain.
Zhen Lei +2 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source