Results 81 to 90 of about 141,401 (262)

Positive Data Visualization Using Trigonometric Function

open access: yesJournal of Applied Mathematics, 2012
A piecewise rational trigonometric cubic function with four shape parameters has been constructed to address the problem of visualizing positive data.
Farheen Ibraheem   +3 more
doaj   +1 more source

Strong rational connectedness of surfaces [PDF]

open access: yesJournal für die reine und angewandte Mathematik (Crelles Journal), 2012
We discuss the strong rational connectedness of smooth rationally connected surfaces. We prove in lots of cases, including the smooth locus of a log del Pezzo surface, the rational connectedness indeed implies the strong rational conectedness. This confirms a conjecture due to Hassett and Tschinkel in \cite{ht08}.
openaire   +5 more sources

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon   +11 more
wiley   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang   +4 more
wiley   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs   +7 more
wiley   +1 more source

Reducing the Friction Coefficient of Heavy-Load Spherical Bearings in Bridges Using Surface Texturing—A Numerical Study

open access: yesLubricants
Spherical bearings play a crucial role in maintaining the safety of bridge systems. The frequent operation and wear rate over their lifespan highlight the necessity for methods to improve their tribological performance.
Qian Hu, Qingxiang Pei, Pei Li
doaj   +1 more source

Arterial Spin‐Labeling MRI at the Cortical‐CSF Interface: A Novel Biomarker in Alzheimer Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background/Objective Arterial spin‐labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF‐adjacent water transport physiology. We developed an automated pipeline to extract cortical‐CSF interface (IF) perfusion for comparison between Alzheimer disease (AD) and cognitively normal ...
Mona Asghariahmadabad   +22 more
wiley   +1 more source

Rational cuspidal curves with four cusps on Hirzebruch surfaces

open access: yesLe Matematiche, 2014
The purpose of this article is to shed light on the question of how many and what kind of cusps a rational cuspidal curve on a Hirzebruch surface can have.
Torgunn Karoline Moe
doaj  

An isogeometric Reissner–Mindlin shell element based on mixed grid

open access: yesAdvances in Mechanical Engineering, 2018
We propose in this article a new isogeometric Reissner–Mindlin degenerated shell element for linear analysis. It is based on the mixed use of non-uniform rational basis spline and Lagrange basis functions in the same domain.
Zhen Lei   +2 more
doaj   +1 more source

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