Results 61 to 70 of about 159,936 (305)
Smooth Rational Curves on Singular Rational Surfaces [PDF]
Michigan Mathematical Journal, 2018 We classify all complex surfaces with quotient singularities that do not contain any smooth rational curves, under the assumption that the canonical divisor of the surface is not pseudo-effective. As a corollary we show that if $X$ is a log del Pezzo surface such that for every closed point $p\in X$, there is a smooth curve (locally analytically ...
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
On the classification of rational surface singularities
, 2012 A general strategy is given for the classification of graphs of rational surface singularities. For each maximal rational double point configuration we investigate the possible multiplicities in the fundamental cycle. We classify completely certain types
Stevens, Jan, Jan Stevens, Stevens, Jan,
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地质科技通报, 2022 An extremely high sulfate content is one of the main reasons for the deterioration of karst water quality in the Xin′an Spring area. Identifying the source of sulfate is of great significance for fully understanding the hydrogeochemical process in karst ...
Xiaobing Hu +6 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Kyoto Journal of Mathematics, 1960 In §1 of the present paper, we introduce the notion of a virtual linear system on a non-singular projective surface and we clarify the theories of infinitely near points, of divisors and of linear system with preassigned base conditions. We introduce in §2 the notions of a numerical types and of non-special points with respect to Cremona ...
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K3 surfaces, rational curves, and rational points
Journal of Number Theory, 2010 10 pages, no figures. An explicit construction of an algebraic point lying on no smooth rational curves has been added to the end, and there have been minor revisions to the rest of the ...
Baragar, Arthur, McKinnon, David
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Determinantal Rational Surface Singularities [PDF]
, 1996 In this paper we give explicit equations for determinantal rational surface singularities and prove dimension formulas for the \(T^1\) and \(T^2\) for those ...
Jong, Theo de
core
The μ-basis and implicitization of a rational parametric surface
, 2005 The concept of a μ-basis was introduced in the case of parametrized curves in 1998 and generalized to the case of rational ruled surfaces in 2001. The μ-basis can be used to recover the parametric equation as well as to derive the implicit equation of a ...
Chen, Falai, Liu, Yang, Cox, David
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