Results 51 to 60 of about 141,401 (262)
Chemosensors, 2021 Here we report the rational development of a carbon dot (CDs)-based fluorescent pH nanosensor by employing an active surface preservation strategy. More specifically, citric acid, urea and fluorescein were subjected to a one-pot hydrothermal treatment ...
Ana Carolina P. Afonso +9 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Smooth Rational Curves on Singular Rational Surfaces [PDF]
Michigan Mathematical Journal, 2018 We classify all complex surfaces with quotient singularities that do not contain any smooth rational curves, under the assumption that the canonical divisor of the surface is not pseudo-effective. As a corollary we show that if $X$ is a log del Pezzo surface such that for every closed point $p\in X$, there is a smooth curve (locally analytically ...
openaire +4 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
地质科技通报, 2022 An extremely high sulfate content is one of the main reasons for the deterioration of karst water quality in the Xin′an Spring area. Identifying the source of sulfate is of great significance for fully understanding the hydrogeochemical process in karst ...
Xiaobing Hu +6 more
doaj +1 more source
Rational Surfaces with Many Nodes [PDF]
Compositio Mathematica, 2002 We describe smooth rational projective algebraic surfaces over an algebraically closed field of characteristic different from 2 which contain $n \geq b_2-2$ disjoint smooth rational curves with self-intersection −2, where $b_2$ is the second Betti ...
DOLGACHEV I. +2 more
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
An Affine Model of a Riemann Surface Associated to a Schwarz–Christoffel Mapping
Axioms, 2021 In this paper, we construct an affine model of a Riemann surface with a flat Riemannian metric associated to a Schwarz–Christoffel mapping of the upper half plane onto a rational triangle.
Richard Cushman
doaj +1 more source
K3 surfaces, rational curves, and rational points
Journal of Number Theory, 2010 10 pages, no figures. An explicit construction of an algebraic point lying on no smooth rational curves has been added to the end, and there have been minor revisions to the rest of the ...
Baragar, Arthur, McKinnon, David
openaire +3 more sources