Results 41 to 50 of about 141,401 (262)
Nonnegativity Preserving Interpolation by C1 Bivariate Rational Spline Surface
This paper is concerned with the nonnegativity preserving interpolation of data on rectangular grids. The function is a kind of bivariate rational interpolation spline with parameters, which is C1 in the whole interpolation region.
Xingxuan Peng, Zhihong Li, Qian Sun
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Parameterization of rational translational surfaces [PDF]
Agencia Estatal de ...
Sonia Pérez-Díaz, Li-Yong Shen
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Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
From the observed datasets, we should be able to produce curve surfaces that have the same characteristics as the original datasets. For instance, if the given data are positive, then the resulting curve or surface must be positive on entire given ...
Samsul Ariffin Abdul Karim +2 more
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In §1 of the present paper, we introduce the notion of a virtual linear system on a non-singular projective surface and we clarify the theories of infinitely near points, of divisors and of linear system with preassigned base conditions. We introduce in §2 the notions of a numerical types and of non-special points with respect to Cremona ...
openaire +3 more sources
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Study region: This study was conducted in Dire Dawa city, Ethiopia. Study focus: This study aims to explore the hydrological impacts of land use land cover changes using rational method.
Sitotaw Haile Erena, Hailu Worku
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The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source

