Results 31 to 40 of about 44,026 (267)

The Efficacy and Safety of Bevacizumab/Irinotecan/Temozolomide (BIT) for Relapsed/Refractory Neuroblastoma: The UK Children's Cancer and Leukaemia Group Experience

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Patients with high‐risk neuroblastoma who either are refractory to induction chemotherapy or relapse following multi‐modal treatment have a dismal prognosis. Based on data from the BEACON trial, since 2021 the UK national guidelines recommend bevacizumab, irinotecan, and temozolomide (BIT) for patients with relapsed/refractory ...
Thomas J. Jackson, Menna Shamma, Upeka Senanayake, Shaimaa Sahmoud, Kathleen Duffin, Victoria Howard, David King, Ayesha Fathani, Blanche Lumb, Andrei Pobischan, Irum Latif Memon, Monzir Ahmed, Rhian Thomas, Gerard Millen, Yasmeen Alomari, Sucheta Vaidya, Lynley V. Marshall, Sally L. George, Ramya Ramanujachar, Juliet Gray, Paola Angelini   +20 more
wiley   +1 more source

Intraoperative Collection of Ascitic Fluid With Intra‐ or Postoperative Reinfusion in Ovarian Cancer: Safety and Feasibility of a Roller Pumping Method

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Patients with ovarian cancer often present with massive ascites, leading to significant protein loss during surgical procedures. Although cell‐free concentrated ascites reinfusion therapy (CART) is used in palliative settings to mitigate protein loss, its application in intraoperative settings remains unexplored.
Yutaka Yoneoka, Tsukuru Amano, Akimasa Takahashi, Mari Deguchi, Hiroyuki Yamanaka, Yuji Tanaka, Shunichiro Tsuji, Takashi Murakami   +7 more
wiley   +1 more source

Collective incentives reduce over-exploitation of social information in unconstrained human groups

Nature Communications
Collective dynamics emerge from countless individual decisions. Yet, we poorly understand the processes governing dynamically-interacting individuals in human collectives under realistic conditions.
Dominik Deffner, David Mezey, Benjamin Kahl, Alexander Schakowski, Pawel Romanczuk, Charley M. Wu, Ralf H. J. M. Kurvers   +6 more
doaj   +1 more source

Pooling decisions decreases variation in response bias and accuracy

iScience, 2021
Summary: Decision makers in contexts as diverse as medical, judicial, and political decision making are known to differ substantially in response bias and accuracy, and these differences are a major factor undermining the reliability and fairness of the ...
Ralf H.J.M. Kurvers, Stefan M. Herzog, Ralph Hertwig, Jens Krause, Max Wolf   +4 more
doaj   +1 more source

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Strategic disinformation outperforms honesty in competition for social influence

iScience, 2021
Summary: Competition for social influence is a major force shaping societies, from baboons guiding their troop in different directions, to politicians competing for voters, to influencers competing for attention on social media.
Ralf H.J.M. Kurvers, Uri Hertz, Jurgis Karpus, Marta P. Balode, Bertrand Jayles, Ken Binmore, Bahador Bahrami   +6 more
doaj   +1 more source

Rationing conscience [PDF]

Journal of Medical Ethics, 2016
Decisions about allocation of limited healthcare resources are frequently controversial. These decisions are usually based on careful analysis of medical, scientific and health economic evidence. Yet, decisions are also necessarily based on value judgements.
openaire   +3 more sources

Rationalizing rational expectations: Characterizations and tests

Quantitative Economics, 2021
In this paper, we build a new test of rational expectations based on the marginal distributions of realizations and subjective beliefs. This test is widely applicable, including in the common situation where realizations and beliefs are observed in two different data sets that cannot be matched.
D'Haultfoeuille, Xavier, Gaillac, Christophe, Maurel, Arnaud   +2 more
openaire   +6 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Earlier social information has a stronger influence on judgments

Scientific Reports
People’s decisions are often informed by the choices of others. Evidence accumulation models provide a mechanistic account of how such social information enters the choice process.
Alan Novaes Tump, David Wollny-Huttarsch, Lucas Molleman, Ralf H. J. M. Kurvers   +3 more
doaj   +1 more source