Results 71 to 80 of about 1,523,647 (396)
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Pubertal testosterone correlates with adolescent impatience and dorsal striatal activity
Developmental Cognitive Neuroscience, 2020 Recent self-report and behavioral studies have demonstrated that pubertal testosterone is related to an increase in risky and impulsive behavior. Yet, the mechanisms underlying such a relationship are poorly understood.
Corinna Laube +2 more
doaj +1 more source
Rational rationalization and System 2 [PDF]
Behavioral and Brain Sciences, 2020 Abstract In this commentary, I highlight the relevance of Cushman's target article for the popular dual-process framework of thinking. I point to the problematic characterization of rationalization in traditional dual-process models and suggest that in line with recent advances, Cushman's rational rationalization account offers a way out of the ...
openaire +2 more sources
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Judgment and Decision Making, 2018 In many sports contests, the equilibrium requires players to randomize across repeated rounds, i.e., exhibit no temporal predictability. Such sports data present a window into the (in)efficiency of random sequence generation in a natural competitive ...
Leonidas Spiliopoulos
doaj +1 more source
The Myth of Instrumental Rationality
, 2017 The paper distinguishes between instrumental reasons and instrumental rationality. It argues that instrumental reasons are not reasons to take the means to our ends.
J. Raz
semanticscholar +1 more source
Many faces of rationality: Implications of the great rationality debate for clinical decision‐making
Journal of Evaluation In Clinical Practice, 2017 Given that more than 30% of healthcare costs are wasted on inappropriate care, suboptimal care is increasingly connected to the quality of medical decisions. It has been argued that personal decisions are the leading cause of death, and 80% of healthcare
B. Djulbegovic, Shira Elqayam
semanticscholar +1 more source
Rational design of bi‐phase CaV2O6/NaV6O15 cathode materials for long‐life aqueous zinc batteries [PDF]
, 2023 Ying Liu, Yi Liu, Xiang Wu
openalex +1 more source
QJM, 2010 With potential budget claw backs of 20% to be found in UK health care in forthcoming years, the question arises as to how these might be achieved. Based on the long-standing economic principle of marginal analysis, a framework for managing such a National Health Service credit crunch is outlined. The framework incorporates not only the natural starting
Donaldson, Cam +4 more
openaire +3 more sources