Results 1 to 10 of about 11,802 (112)

The effects of buprenorphine on behaviour in the ACI and BN rat inbred strains [PDF]

Laboratory Animals, 2008
Summary Buprenorphine is a partial μ, κ agonist that has been shown to influence spontaneous behaviour in animals. Previously, we have demonstrated significant differences in the analgesic response to buprenorphine between the August Copenhagen Irish (ACI)/SegHsd and the Brown Norway (BN)/RijHsd inbred rat strains.
Avsaroglu, H., Sommer, R., Hellebrekers, L.J., van Zutphen, L.F.M., van Lith, H.A.   +4 more
openaire   +6 more sources

Nest-building behaviour in male rats from three inbred strains: BN/HsdCpb, BDIX/Or1Ico and LEW/Mol

Animal Welfare, 2005
AbstractThree inbred strains of male laboratory rat (BN/HsdCpb, BDIX/Or1Ico and LEW/Mol) were provided with nest boxes and nest materials, and were observed for nest-building activity. After 7 days, each cage and nest box was examined. Each nest was weighed and scored for complexity, and returned to the cage.
IM Jegstrup, R Vestergaard, W Vach, M Ritskes-Hoitinga   +3 more
openaire   +2 more sources

Phenotypic and Gene Expression Differences between DA, BN and WOKW Rats

PLoS ONE, 2012
Background Because inbred rat strains are widely used as laboratory models, knowledge of phenotypic and genetic variations between strains will be useful to obtain insight into the relationship between different strains.
J. Lange, T. Barz, A. Ekkernkamp, B. Wilke, I. Klöting, N. Follak   +5 more
semanticscholar   +1 more source

Spontaneous Recurrent Absence Seizure-like Events in Wild-Caught Rats

Journal of Neuroscience, 2019
Absence epilepsy is a heritable human neurological disorder characterized by brief nonconvulsive seizures with behavioral arrest, moderate-to-severe loss of consciousness (absence), and distinct spike-wave discharges (SWDs) in the EEG and ...
Jeremy A. Taylor, Jon D. Reuter, Rebecca A. Kubiak, Toni T. Mufford, Carmen J. Booth, F. Dudek, Daniel S. Barth   +6 more
semanticscholar   +1 more source

Sex-specific nicotine sensitization and imprinting of self-administration in rats inform GWAS findings on human addiction phenotypes

Neuropsychopharmacology, 2021
Repeated nicotine exposure leads to sensitization (SST) and enhances self-administration (SA) in rodents. However, the molecular basis of nicotine SST and SA and their biological relevance to the mounting genome-wide association study (GWAS) loci of ...
A. Kozlova, R. Butler, Siwei Zhang, T. Ujas, Hanwen Zhang, S. Steidl, A. Sanders, Z. Pang, P. Vezina, J. Duan   +9 more
semanticscholar   +1 more source

Five‐Minute Apgar Scores and Its Prognostic Value for Mortality and Severe Morbidity in Very Preterm Infants: A Multinational Cohort Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To examine associations between a 5‐min Apgar score < 7 and severe neonatal outcomes in very preterm (VPT) infants and how results are impacted by variations in assigning Apgar scores within an international context. Design Prospective observational population‐based cohort study.
Harald Ehrhardt, Soodabeh Behboodi, Rolf F. Maier, Adrien M. Aubert, Ulrika Åden, Elizabeth S. Draper, Anna Gudmundsdottir, Veronica Siljehav, Heili Varendi, Tom Weber, Michael Zemlin, Jennifer Zeitlin, on behalf of the EPICE/SHIPS Research Group, J. Lebeer, P. Van Reempts, E. Bruneel, E. Cloet, A. Oostra, E. Ortibus, I. Sarrechia, K. Boerch, L. Huusom, P. Pedersen, T. Weber, A. Hasselager, L. Toome, H. Varendi, M. Männamaa, P. Y. Ancel, A. Burguet, P. H. Jarreau, V. Pierrat, P. Truffert, R. F. Maier, M. Zemlin, B. Misselwitz, S. Schmidt, L. Wohlers, M. Cuttini, D. Di Lallo, G. Ancora, D. Baronciani, V. Carnielli, I. Croci, G. Faldella, F. Ferrari, F. Franco, G. Gargano, A. van Heijst, C. Koopman‐Esseboom, J. Gadzinowski, J. Mazela, A. Montgomery, T. Pikuła, H. Barros, R. Costa, L. Mendes Graça, M. do Céu Machado, C. Rodrigues, T. Rodrigues, U. Aden, A. K. Edstedt Bonamy, M. Norman, E. S. Draper, E. M. Boyle, A. Fenton, S. J. Johnson, B. N. Manktelow, D. W. A. Milligan, S. Mader, N. Thiele, J. Walz, S. Petrou, J. Zeitlin, M. Bonet, C. Bonnet, R. El Raffei, A. Piedvache, A. V. Seppanen, A. M. Aubert   +79 more
wiley   +1 more source

Real‐World Therapeutic Hypothermia for Neonatal HIE: Neurodevelopmental Outcomes and Predictors

Acta Paediatrica, EarlyView.
ABSTRACT Aim This study assessed neurodevelopmental outcomes in neonates with hypoxic‐ischemic encephalopathy (HIE) treated with therapeutic hypothermia (TH) outside randomised controlled trials (RCTs). It also aimed to identify predictors of outcomes and evaluate TH practices across centres.
Luca Bedetti, Licia Lugli, Isotta Guidotti, Maria Federica Roversi, Elisa Della Casa Muttini, Marisa Pugliese, Natascia Bertoncelli, Eugenio Spaggiari, Alessandra Todeschini, Gina Ancora, Sara Grandi, Giancarlo Gargano, Claudio Gallo, Mario Motta, Piero Catenazzi, Luigi Tommaso Corvaglia, Vittoria Paoletti, Agostina Solinas, Elisa Ballardini, Serafina Perrone, Sabrina Moretti, Marcello Stella, Alberto Berardi, Fabrizio Ferrari   +23 more
wiley   +1 more source

The RhoA guanine exchange factor ABR: a glucose‐sensitive mediator of actin reorganization in feto‐placental arterial endothelial cells altered by gestational diabetes mellitus

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of proposed relationship between hyperglycaemia, gestational diabetes mellitus (GDM), active BCR‐related (ABR), RhoA and actin organization of feto‐placental arterial endothelial cells (fpEC). Hyperglycaemia upregulates ABR, which in turn increases RhoA activation.
Silvija Tokic, Boris Novakovic, Barbara Leopold‐Posch, Magdalena Mühlberger, Denise Hoch, Jelena Lögl, Eva M. Bernhart, Richard Saffery, Gernot Desoye, Ursula Hiden   +9 more
wiley   +1 more source

Organ Specificity and Commonality of Epigenetic Aging in Low‐ and High‐Running Capacity Rats

Aging Cell, Volume 24, Issue 8, August 2025.
Cardiorespiratory fitness (CRF) is not associated with epigenetic clocks, including newly developed ones. On the other hand, CRF is associated with global methylation profiles and promoter methylation in organ‐specific and organ‐common manner. ABSTRACT Epigenetic drift, which is gradual age‐related changes in DNA methylation patterns, plays a ...
Takuji Kawamura, Csaba Kerepesi, Juliet Polok Sarkar, Ferenc Torma, Zoltan Bori, Lei Zhou, Peter Bakonyi, Attila Kolonics, Laszlo Balogh, Mitsuru Higuchi, Vivien Pillár, Karolina Pircs, Lauren Gerard Koch, Steven Loyal Britton, Erika Koltai, Zsolt Radak   +15 more
wiley   +1 more source

Less Invasive Surfactant Administration Versus Intubate‐Surfactant‐Extubate: Associated With Reduced Mechanical Ventilation in Extremely Preterm Infants

Acta Paediatrica, Volume 114, Issue 8, Page 1868-1876, August 2025.
ABSTRACT Aim To compare less invasive surfactant administration (LISA) and intubation‐surfactant‐extubation (INSURE) in infants born before 28 weeks gestational age (GA) by the need for mechanical ventilation (MV). Methods LISA was introduced in 2017 in our unit without formal prior LISA‐specific training as an equal alternative to INSURE.
C. Heiring, S. S. Hedegaard, E. M. Carlsen, R. Kristensen, N. Breindahl, C. Schmidt, E. T. Bay, I. M. L. Nyegaard, T. B. Henriksen, L. Aunsholt   +9 more
wiley   +1 more source