Results 1 to 10 of about 3,164 (85)

Hi-C sequencing data from frontal cortex of laboratory rats [PDF]

Scientific Data
The three-dimensional structure of chromosomes is integral to nuclear organization and influences processes such as DNA replication, repair, and gene expression.
Panjun Kim, Rachel R. Ward, Burt M. Sharp, Robert W. Williams, Hao Chen   +4 more
doaj   +2 more sources

Lower developmental potential of rat zygotes produced by ooplasmic injection of testicular spermatozoa versus cauda epididymal spermatozoa [PDF]

The Journal of Reproduction and Development
Intracytoplasmic sperm injection (ICSI) is clinically used to treat obstructive/nonobstructive azoospermia. This study compared the efficacy of ICSI with cauda epididymal and testicular sperm in Wistar (WI) and Brown-Norway (BN) rats.
Misuzu IDE, Ibuki SAITO, Makoto SANBO, Mito KANATSU-SHINOHARA, Takashi SHINOHARA, Masumi HIRABAYASHI, Shinichi HOCHI   +6 more
doaj   +2 more sources

Rapid eye movement sleep deprivation induced gene regulation for modulation of noradrenaline level in brain regions of rats: Implications with chronic sleep-loss associated pathophysiological conditions. [PDF]

Neuroprotection
Proposed mechanism for transcriptional regulation of tyrosine hydroxylase (TH), dopamine β hydroxylase (DBH) and monoamine oxidase‐A (MAO‐A) genes during rapid eye movement sleep (REMS) or its loss. Increased histone acetylation and decreased histone methylation of TH and DBH gene favor chromatin opening, increase in gene expressions, increased enzyme ...
Mehta R, Murali R, Mallick BN.
europepmc   +2 more sources

Phenotypic and gene expression differences between DA, BN and WOKW rats. [PDF]

PLoS ONE, 2012
BACKGROUND: Because inbred rat strains are widely used as laboratory models, knowledge of phenotypic and genetic variations between strains will be useful to obtain insight into the relationship between different strains.
Jörn Lange, Thomas Barz, Axel Ekkernkamp, Barbara Wilke, Ingrid Klöting, Niels Follak   +5 more
doaj   +1 more source

The effects of buprenorphine on behaviour in the ACI and BN rat inbred strains [PDF]

Laboratory Animals, 2008
Summary Buprenorphine is a partial μ, κ agonist that has been shown to influence spontaneous behaviour in animals. Previously, we have demonstrated significant differences in the analgesic response to buprenorphine between the August Copenhagen Irish (ACI)/SegHsd and the Brown Norway (BN)/RijHsd inbred rat strains.
Avsaroglu, H., Sommer, R., Hellebrekers, L.J., van Zutphen, L.F.M., van Lith, H.A.   +4 more
openaire   +4 more sources

Genetic etiology of renal agenesis: fine mapping of Renag1 and identification of Kit as the candidate functional gene. [PDF]

PLoS ONE, 2015
Congenital anomalies of the kidney and urogenital tract (CAKUT) occur in approximately 0.5% of live births and represent the most frequent cause of end-stage renal disease in neonates and children. The genetic basis of CAKUT is not well defined.
Nyssa Becker Samanas, Tessa W Commers, Kirsten L Dennison, Quincy Eckert Harenda, Scott G Kurz, Cynthia M Lachel, Kristen Leland Wavrin, Michael Bowler, Isaac J Nijman, Victor Guryev, Edwin Cuppen, Norbert Hubner, Ruth Sullivan, Chad M Vezina, James D Shull   +14 more
doaj   +1 more source

A variable CD3⁺ T-cell frequency in peripheral blood lymphocytes associated with type 1 diabetes mellitus development in the LEW.1AR1-iddm rat. [PDF]

PLoS ONE, 2013
PURPOSE: The LEW.1AR1-iddm rat is an animal model of human type 1 diabetes mellitus (T1DM), which arose through a spontaneous mutation within the MHC-congenic inbred strain LEW.1AR1 (RT1(r²)).
Tanja Arndt, Anne Jörns, Heike Weiss, Markus Tiedge, Hans-Jürgen Hedrich, Sigurd Lenzen, Dirk Wedekind   +6 more
doaj   +1 more source

MicroRNA-125a is over-expressed in insulin target tissues in a spontaneous rat model of Type 2 Diabetes

BMC Medical Genomics, 2009
Background MicroRNAs (miRNAs) are non-coding RNA molecules involved in post-transcriptional control of gene expression of a wide number of genes, including those involved in glucose homeostasis.
Fernandez Christina, Camps Carme, Barrett Amy, Kaisaki Pamela J, Wills Quin F, Taylor Jennifer M, Lockstone Helen E, Herrera Blanca M, Ragoussis Jiannis, Gauguier Dominique, McCarthy Mark I, Lindgren Cecilia M   +11 more
doaj   +1 more source

Genetic control of differential acetylation in diabetic rats.

PLoS ONE, 2014
Post-translational protein modifications such as acetylation have significant regulatory roles in metabolic processes, but their relationship to both variation in gene expression and DNA sequence is unclear. We address this question in the Goto-Kakizaki (
Pamela J Kaisaki, Georg W Otto, Joanna F McGouran, Amine Toubal, Karène Argoud, Helen Waller-Evans, Clare Finlay, Sophie Caldérari, Marie-Thérèse Bihoreau, Benedikt M Kessler, Dominique Gauguier, Richard Mott   +11 more
doaj   +1 more source

Transcriptome Profiling in Rat Inbred Strains and Experimental Cross Reveals Discrepant Genetic Architecture of Genome-Wide Gene Expression

G3: Genes, Genomes, Genetics, 2016
To test the impact of genetic heterogeneity on cis- and trans-mediated mechanisms of gene expression regulation, we profiled the transcriptome of adipose tissue in 20 inbred congenic strains derived from diabetic Goto–Kakizaki (GK) rats and Brown–Norway (
Pamela J. Kaisaki, Georg W. Otto, Karène Argoud, Stephan C. Collins, Robert H. Wallis, Steven P. Wilder, Anthony C. Y. Yau, Christophe Hue, Sophie Calderari, Marie-Thérèse Bihoreau, Jean-Baptiste Cazier, Richard Mott, Dominique Gauguier   +12 more
doaj   +1 more source