Results 1 to 10 of about 6,282 (152)

Mechanisms altering airway smooth muscle cell Ca(2+) homeostasis in two asthma models [PDF]

, 2008
Background: Asthma is characterized by airway remodeling, altered mucus production and airway smooth muscle cell (ASMC) contraction causing extensive airway narrowing. In particular, alterations of ASMC contractility seem to be of crucial importance. The
Bergner, Albrecht, Edelmann, Martin, Fischer, Rainald, Huber, Rudolf M., Kellner, Julia, Oelmez, Hamza, Tantzscher, Juliane   +6 more
core   +1 more source

Cerebellar output controls generalized spike-and-wave discharge occurence [PDF]

, 2015
© 2015 The Authors Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (CC BY-NC-ND 4.0)
Alva, Parimala, Davey, N., De Zeeuw, Chris I., Eelkman Rooda, Oscar, Hoebeek, Freek E., Karapatis, Athanasios, Kros, Lieke, Negrello, Mario, Serdijn, Wouter, Spanke, Jochen, Steuber, Volker, Strydis, Christos, Tolner, Else, van den Maagdenberg, Arn, van Dongen, Marijn, Winkelman, Beerend   +15 more
core   +8 more sources

Adolescent D-amphetamine treatment in a rodent model of ADHD: pro-cognitive effects during adolescence and cocaine abuse risk during adulthood [PDF]

, 2015
Attention-deficit/hyperactivity disorder (ADHD) is comorbid with cocaine abuse. Whereas initiating ADHD medication in childhood does not alter later cocaine abuse risk, initiating medication during adolescence may increase risk.
Baskin, Britahny M., Dwoskin, Linda P., Jeon, Sae-Mi, Jordan, Chloe J., Kantak, Kathleen M., Taylor, Danielle M.   +5 more
core   +1 more source

Small RNA expression and strain specificity in the rat [PDF]

, 2010
Background Digital gene expression (DGE) profiling has become an established tool to study RNA expression. Here, we provide an in-depth analysis of small RNA DGE profiles from two different rat strains (BN-Lx and SHR) from six different rat tissues ...
Sam EV Linsen, Elzo de Wit, Ewart de Bruijn, Edwin Cuppen   +3 more
core   +1 more source

Identification of a Novel Gene for Diabetic Traits in Rats, Mice, and Humans [PDF]

, 2014
The genetic basis of type 2 diabetes remains incompletely defined despite the use of multiple genetic strategies. Multiparental populations such as heterogeneous stocks (HS) facilitate gene discovery by allowing fine mapping to only a few megabases ...
Andrae, Jaime Wendt, Galione, Antony, He, Hong, Hessner, Martin, Hoffmann, Raymond G., Holl, Katie, Jacob, Howard, Jia, Shuang, Kaldunski, Mary, Li, Shun-Hua, Meigs, James, Parrington, John, Ruas da Silva, Margarida, Simpson, Pippa, Solberg Woods, Leah C., Stoddard, Alex, Tsaih, Shirng-Wern, Tschannen, Michael, Wiederhold, Andrew   +18 more
core   +1 more source

Heterotopic heart transplantation in the rat receiving FK-506 alone or with cyclosporine. [PDF]

, 1987
In rats, FK significantly prolonged heterotopic heart graft survival over a wide dose range when given for 2 weeks starting on the day of the operation.
Chapman, F, Lai, HS, Lee, PH, Makowka, L, Murase, N, Nalesnik, MA, Starzl, TE, Todo, S   +7 more
core  

Adolescent D-amphetamine treatment in a rodent model of ADHD: pro-cognitive effects in adolescence without an impact on cocaine cue reactivity in adulthood [PDF]

, 2016
Attention-deficit/hyperactivity disorder (ADHD) is comorbid with cocaine abuse. Whereas initiating ADHD medication in childhood does not alter later cocaine abuse risk, initiating medication during adolescence may increase risk.
Dwoskin, Linda P., Jordan, Chloe J., Kantak, Kathleen M., Taylor, Danielle M.   +3 more
core   +1 more source

Topological Analysis of Metabolic Networks Integrating Co-Segregating Transcriptomes and Metabolomes in Type 2 Diabetic Rat Congenic Series [PDF]

, 2016
Background: The genetic regulation of metabolic phenotypes (i.e., metabotypes) in type 2 diabetes mellitus is caused by complex organ-specific cellular mechanisms contributing to impaired insulin secretion and insulin resistance.
Argoud, K, Ayala, R, Calderari, S, Cazier, JB, Collins, S, Domange, C, Dumas, ME, Gauguier, D, Gu, Q, Holmes, E, Hue, C, Lindon, JC, Mitchell, S, Navratil, V, Nicholson, JK, Otto, GW, Rodriguez Martinez, A, Suárez-Zamorano, N, Wallis, R, Wang, Y, Wilder, S   +20 more
core   +6 more sources

Home Cage Compared with Induction Chamber for Euthanasia of Laboratory Rats [PDF]

, 2018
This study compared behavioral and physiologic changes in Sprague-Dawley and Brown Norway rats that were euthanizedby using a 30% volume displacement rate of CO2 in either their home cage or an induction chamber; rats euthanized in thehome cage were ...
Hickman, Debra L.
core   +1 more source

Reduced Levels of mGlu2 Receptors within the Prelimbic Cortex Are Not Associated with Elevated Glutamate Transmission or High Alcohol Drinking [PDF]

, 2017
Background A Grm2 cys407* stop codon mutation, which results in a loss of the metabotropic glutamate 2 (mGlu2) receptor protein, was identified as being associated with high alcohol drinking by alcohol-preferring (P) rats.
Bell, Richard L., Ding, Zheng-Ming, Hauser, Sheketha R., Ingraham, Cynthia M., Lasek, Amy W., McBride, William J.   +5 more
core   +1 more source