In the current research, an optimized ultrasound‐assisted extraction method was developed for extracting anthocyanin from Berberis kaschgarica Rupr. fruits. The extract was purified and its effects were evaluated against hypertension in the rat model. The developed UAE method was found suitable for high‐yield anthocyanin extraction.
Nawaz Khan +10 more
wiley +1 more source
Re‐evaluation of saccharin and its sodium, potassium and calcium salts (E 954) as food additives
Abstract This opinion deals with the re‐evaluation of saccharin and its sodium, potassium and calcium salts (E 954) as food additives. Saccharin is the chemically manufactured compound 1,2‐benzisothiazol‐3(2H)‐one‐1,1‐dioxide. Along with its sodium (Na), potassium (K) and calcium (Ca) salts, they are authorised as sweeteners (E 954).
EFSA Panel on Food Additives and Flavourings (FAF) +42 more
wiley +1 more source
Sex differences in primary hypertension [PDF]
Men have higher blood pressure than women through much of life regardless of race and ethnicity. This is a robust and highly conserved sex difference that it is also observed across species including dogs, rats, mice and chickens and it is found in ...
Kathryn Sandberg, Hong Ji
core +1 more source
We aimed at assessing anxiety‐ and depressive‐like behaviors in Wistar‐Kyoto (WKY) rats and determining whether these were associated to changes in levels of neuroinflammatory markers (Iba‐1, CD86, Ym1, GFAP, S100A10) and mediators (interleukins IL‐1β, IL‐6, TNF‐α) in the prefrontal cortex (PFC), hippocampus, and amygdala.
Miguel Farinha‐Ferreira +5 more
wiley +1 more source
Effects of the overlapping between an experimental model of neuroendocrine obesity with arterial hypertension under blood pressure, body weight and metabolic and renal parameters in rats [PDF]
INTRODUCTION: Increased body mass index and the metabolic syndrome are associated with decreased renal function and the development of end-stage kidney disease. OBJECTIVE: To evaluate the effect of the overlap between an experimental model of obesity and
Cesaretti, Mario Luis Ribeiro +4 more
core +2 more sources
Spontaneous vascular dysfunction in Dahl salt‐sensitive male rats raised without a high‐salt diet
Abstract Dahl salt‐sensitive (SS) rats fed a high‐salt diet, but not low‐salt, exhibit vascular dysfunction. Several substrains of SS rats exist that differ in their blood pressure phenotypes and salt sensitivity. The goal of this study was to investigate whether the John‐Rapp‐derived SS rat (SS/Jr), which exhibits spontaneous hypertension on a low ...
Arturo Grano de Oro +5 more
wiley +1 more source
Discharge of RVLM vasomotor neurons is not increased in anesthetized angiotensin II-salt hypertensive rats [PDF]
Neurons of the rostral ventrolateral medulla (RVLM) are critical for generating and regulating sympathetic nerve activity (SNA). Systemic administration of ANG II combined with a high-salt diet induces hypertension that is postulated to involve elevated ...
Andrade, Mary Ann +4 more
core +2 more sources
Vascular NADH/NADPH oxidase is involved in enhanced superoxide production in spontaneously hypertensive rats [PDF]
This study was designed to test the hypothesis that stimulation of nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phosphate (NADH/NADPH) oxidase is involved in increased vascular superoxide anion (*O(2)(-)) production in ...
Beaumont, J. (Javier) +6 more
core +1 more source
Abstract Taking into account homeostatic disorders resulting from arterial hypertension and the key importance of CacyBP/SIP, β‐catenin and endocannabinoids in the functioning of many organs, it was decided to assess the presence and distribution of CacyBP/SIP, β‐catenin, CB1 and CB2 in the adrenal glands of hypertensive rats of various aetiology.
Magdalena Smereczańska +3 more
wiley +1 more source
Systemic hemodynamic and left ventricular function of diabetic-induced hypertensive rats [PDF]
OBJECTIVE: To analyze the effects of type-1 diabetes mellitus (DM1) induction on systemic hemodynamic and ventricular function of normotensive and hypertensive rats.
Cesaretti, Mário Luís Ribeiro +3 more
core +2 more sources

