Results 121 to 130 of about 68,662 (250)

Systems Genetics Approaches in Rat Identify Novel Genes and Gene Networks Associated With Cardiac Conduction

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Electrocardiographic (ECG) parameters are regarded as intermediate phenotypes of cardiac arrhythmias. Insight into the genetic underpinnings of these parameters is expected to contribute to the understanding of cardiac arrhythmia mechanisms ...
Michiel E. Adriaens, Elisabeth M. Lodder, Aida Moreno‐Moral, Jan Šilhavý, Matthias Heinig, Charlotte Glinge, Charly Belterman, Rianne Wolswinkel, Enrico Petretto, Michal Pravenec, Carol Ann Remme, Connie R. Bezzina   +11 more
doaj   +1 more source

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source

Creation of a Computational Pipeline to Extract Genes from Quantitative Trait Loci for Diabetes and Obesity [PDF]

, 2015
Type 2 Diabetes is a disease of relative insulin deficiency resulting from a combination of insulin resistance and decreased beta-cell function. Over the past several years, over 60 genes have been identified for Type 2 Diabetes in human genome-wide ...
Fox, Joseph
core   +1 more source

Demonstration of beat‐to‐beat, on‐demand ATP synthesis in ventricular myocytes reveals sex‐specific mitochondrial and cytosolic dynamics

The Journal of Physiology, EarlyView.
Abstract figure legend Beat‐locked mitochondrial ATP transients reveal modular, sex‐specific bioenergetic control during excitation–contraction coupling. A, each action potential activates L‐type CaV1.2 channels, producing a Ca2+ influx that triggers ryanodine receptors (RyR2) and elicits SR Ca2+ release.
Paula Rhana, Collin Matsumoto, L. Fernando Santana   +2 more
wiley   +1 more source

Feeding Behaviour in the KPC Model of Pancreatic Cancer‐Associated Cachexia: Alteration of Spontaneous and Evoked Feeding Behaviours

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background The KPC mouse model of pancreatic cancer is gaining use in research, but detailed understanding of ingestive behaviour changes in this and other cachexia models is limited. Methods Male C57BL/6 J mice (7 weeks) were maintained under standard feed (PicoLab5L0D) and housing conditions (12:12 h; Light:Dark).
Fateema Muzaffar, William F. Colmers, Vickie E. Baracos   +2 more
wiley   +1 more source

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, Volume 101, Issue 2, Page 751-803, April 2026.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

Factors Affecting Immune Reconstitution Post‐Allogeneic HSCT in Children: The Case for an Individualized Approach to Vaccination

European Journal of Haematology, Volume 116, Issue 4, Page 336-349, April 2026.
ABSTRACT Allogeneic hematopoietic stem cell transplantation (HSCT) is increasingly used to treat malignant and non‐malignant diseases. Following allogeneic HSCT, patients are particularly vulnerable to vaccine‐preventable diseases (VPD) because conditioning depletes immune cells, including memory cells.
Hélène Buvelot, Frederic Baleydier, Laure Pittet, Geraldine Blanchard‐Rohner   +3 more
wiley   +1 more source

Characterization of Social and Repetitive Behaviors of Mllt11/Af1q/TcF7c Conditional Knockout Mice

European Journal of Neuroscience, Volume 63, Issue 7, April 2026.
Sex‐specific neurodevelopmental defects in Mllt11 conditional knockout mice. Females displayed reduced social interest, increased freezing, and decreased nestlet shredding, while males exhibited increased novelty‐seeking behaviors. ABSTRACT Mllt11 (myeloid/lymphoid or mixed‐lineage leukemia translocated to chromosome 11; also known as Af1q/TcF7c) has ...
Emily A. Witt, Danielle Stanton‐Turcotte, Pristine Garay, Jinrong Ge, Angelo Iulianella   +4 more
wiley   +1 more source

Perceived causes of Black–White racial economic inequality and racialized policy attitudes: Implications for policy support

Political Psychology, Volume 47, Issue 2, April 2026.
Abstract Attributing racial disparities to factors related to individuals (individual causes) or to societal factors (structural causes) is linked to attitudes toward racial equity policies. Membership in a dominant or subordinated racial group might shape these associations.
Alicia M. Bowling, Drexler James
wiley   +1 more source

The dimensions of personality in humans and other animals: A comparative and evolutionary perspective [PDF]

, 2000
This paper considers the structure and proximate mechanisms of personality in humans and other animals. Significant similarities were found between personality structures and mechanisms across species in at least two broad traits: Extraversion and ...
Budaev, Dr. Sergey
core