Results 61 to 70 of about 23,411 (167)

Spontaneous vascular dysfunction in Dahl salt‐sensitive male rats raised without a high‐salt diet

Physiological Reports, Volume 12, Issue 14, July 2024.
Abstract Dahl salt‐sensitive (SS) rats fed a high‐salt diet, but not low‐salt, exhibit vascular dysfunction. Several substrains of SS rats exist that differ in their blood pressure phenotypes and salt sensitivity. The goal of this study was to investigate whether the John‐Rapp‐derived SS rat (SS/Jr), which exhibits spontaneous hypertension on a low ...
Arturo Grano de Oro, Sanjana Kumariya, Blair Mell, Jasenka Zubcevic, Bina Joe, Islam Osman   +5 more
wiley   +1 more source

Identification of a Novel Gene for Diabetic Traits in Rats, Mice, and Humans [PDF]

, 2014
The genetic basis of type 2 diabetes remains incompletely defined despite the use of multiple genetic strategies. Multiparental populations such as heterogeneous stocks (HS) facilitate gene discovery by allowing fine mapping to only a few megabases ...
Andrae, Jaime Wendt, Galione, Antony, He, Hong, Hessner, Martin, Hoffmann, Raymond G., Holl, Katie, Jacob, Howard, Jia, Shuang, Kaldunski, Mary, Li, Shun-Hua, Meigs, James, Parrington, John, Ruas da Silva, Margarida, Simpson, Pippa, Solberg Woods, Leah C., Stoddard, Alex, Tsaih, Shirng-Wern, Tschannen, Michael, Wiederhold, Andrew   +18 more
core   +1 more source

Comparative assessment of CacyBP/SIP, β‐catenin and cannabinoid receptors in the adrenals of hypertensive rats

Journal of Cellular and Molecular Medicine, Volume 28, Issue 10, May 2024.
Abstract Taking into account homeostatic disorders resulting from arterial hypertension and the key importance of CacyBP/SIP, β‐catenin and endocannabinoids in the functioning of many organs, it was decided to assess the presence and distribution of CacyBP/SIP, β‐catenin, CB1 and CB2 in the adrenal glands of hypertensive rats of various aetiology.
Magdalena Smereczańska, Natalia Domian, Alicja Lewandowska, Irena Kasacka   +3 more
wiley   +1 more source

Genetic differences in the development of physical dependence on pentobarbital in four inbred strains of rats.

Japanese Journal of Pharmacology, 1987
Fischer 344 (F344), Lewis (LEW), spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats were chronically fed food containing pentobarbital on an escalating drug dosage schedule over a period of 47 days.
Tsutomu Suzuki, Tsutomu Suzuki, Tsutomu Suzuki, Y. Koike, Saizo Yanaura, Frank R. George, Frank R. George, R. Meisch   +7 more
semanticscholar   +1 more source

Dual pharmacological inhibitor of endocannabinoid degrading enzymes reduces depressive-like behavior in female rats.

Journal of Psychiatric Research, 2020
Major depressive disorder (MDD) is common, often under-treated and a leading cause of disability and mortality worldwide. The causes of MDD remain unclear, including the role of the endocannabinoid system.
B. Dong, B. M. Shilpa, Relish Shah, Arjun Goyal, S. Xie, M. Bakalian, R. Suckow, T. Cooper, J. Mann, V. Arango, K. Vinod   +10 more
semanticscholar   +1 more source

Phasic dopamine signals are reduced in the spontaneously hypertensive rat and increased by methylphenidate

European Journal of Neuroscience, Volume 59, Issue 7, Page 1567-1584, April 2024.
Abstract The spontaneously hypertensive rat (SHR) is a selectively bred animal strain that is frequently used to model attention‐deficit hyperactivity disorder (ADHD) because of certain genetically determined behavioural characteristics. To test the hypothesis that the characteristically altered response to positive reinforcement in SHRs may be due to ...
Yu‐Ting Li, Yi‐Ling Huang, Jia‐Jin Jason Chen, Brian Ian Hyland, Jeffery R. Wickens   +4 more
wiley   +1 more source

Effects of Amphetamine on Striatal Dopamine Release, Open-Field Activity, and Play in Fischer 344 and Sprague–Dawley Rats

, 2015
Previous work from our laboratories has shown that juvenile Fischer 344 (F344) rats are less playful than other strains and also appear to be compromised in dopamine (DA) functioning.
Akopian, Garnik, Eck, Samantha R., McDowell, Lana S., Siviy, Stephen M., Turano, Alexandra, Walsh, John P.   +5 more
core   +1 more source

Genetic background and sex influence somatosensory sensitivity and oxycodone analgesia in the Hybrid Rat Diversity Panel

Genes, Brain and Behavior, Volume 23, Issue 2, April 2024.
Using the Hybrid Rat Diversity Panel, we demonstrated that sex and genetic background confer differences in mechanical sensitivity, thermal sensitivity, and oxycodone‐induced analgesia. Created with BioRender.com. Abstract Opioid use disorder (OUD) is an ongoing public health concern in the United States, and relatively little work has addressed how ...
Eamonn P. Duffy, J. O. Ward, L. H. Hale, K. T. Brown, Andrew J. Kwilasz, Laura M. Saba, Marissa A. Ehringer, Ryan K. Bachtell   +7 more
wiley   +1 more source

Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats [PDF]

, 2018
Dementia is a major social and economic problem for our aging population. One of the most common of dementia in the elderly is cerebral small vessel disease (SVD). Magnetic resonance scans of SVD patients typically show white matter abnormalities, but we
Atanur, Santosh S., Dominiczak, Anna F., Fornage, Myriam, Graham, Delyth, Harris, Sarah E., Quick, Sophie, Rajani, Rikesh M., Ruigrok, Silvie R., Seshadri, Sudha, Smith, Colin, Verhaaren, Benjamin F. J., Wardlaw, Joanna M., Williams, Anna   +12 more
core   +3 more sources

Global microRNA expression profiles in insulin target tissues in a spontaneous rat model of type 2 diabetes [PDF]

, 2010
AIMS/HYPOTHESIS: MicroRNAs regulate a broad range of biological mechanisms. To investigate the relationship between microRNA expression and type 2 diabetes, we compared global microRNA expression in insulin target tissues from three inbred rat strains ...
B. M. Herrera, H. E. Lockstone, J. M. Taylor, M. Ria, A. Barrett, S. Collins, P. Kaisaki, K. Argoud, C. Fernandez, M. E. Travers, J. P. Grew, J. C. Randall, A. L. Gloyn, D. Gauguier, M. I. McCarthy, C. M. Lindgren, DP Bartel, Y Liang, J Krutzfeldt, FC Lynn, MN Poy, V Plaisance, BD Mersey, C Esau, TE Callis, MN Poy, J Lu, MN Nikiforova, A He, Y Goto, K Srinivasan, B Portha, D Gauguier, LC Solberg, M Castoldi, RC Gentleman, Y Hochberg, KJ Livak, AJ Enright, A Grimson, P Carmona-Saez, N Begum, B Portha, I Eisenberg, S Xu, CJ Loscher, R Visone, C Sage le, M Selbach, D Baek, K Saar, C Dugovic, CC Will, K Bouzakri, HA Koistinen, Y Leng, D Gauguier, K Argoud, ME Dumas   +58 more
core   +1 more source